消岩汤治疗晚期恶性肿瘤恶液质42例临床观察

Clinical observation of Xiaoyan decoction in treatment of 42 patients with cachexia of the late malignant tumor

关键词:  消岩汤  恶性肿瘤  恶液质

Key words:  Xiaoyan decoction  malignant tumor  cachexia

摘要:

[目的] 观察消岩汤治疗晚期恶性肿瘤恶液质前期或恶液质期的临床疗效。[方法] 将83例晚期恶性肿瘤恶液质患者随机分为治疗组（42例）和对照组（41例），对照组予醋酸甲地孕酮分散片治疗，治疗组在对照组的基础上联合消岩汤，连续观察3个月后，比较两组患者进食量、卡氏评分、体液潴留变化，检测比较治疗前后调整体质量（ABW）和淋巴细胞总数的差异。[结果] 治疗组在提高患者卡氏评分、增加患者进食量及ABW方面优于照组（P<0.05）；治疗组发生体液潴留较对照组少（P<0.05）；在改善生化指标方面，治疗组优于对照组（P<0.05）.[结论] 消岩汤治疗晚期恶性肿瘤恶液质前期或恶液质期疗效较好，能改善患者患者营养状态，减少不良反应发生，提高生活质量。

Abstract:

[Objective] To observe the effect of Xiaoyan decoction on the cachexia of late malignant tumor. [Methods] Eighty-three cases of the cachexia patients were divided into 2 groups, 42 cases in treatment group and 41 cases in control group randomly. Megestrol acetate dispersible tablets were taken orally by the patients of control group. Megestrol acetate dispersible tablets combined with Xiaoyan decoction were taken orally by the patients of treatment group. Three months later, food-intake, Karnofsky performance Score (KPS), fluid retention, adjusted body weight(ABW) and the total lymphocyte count were compared before and after treatment between two groups. [Results] The improvement of KPS, ABW and the increase of food-intake of the treatment group were better than the control group(P<0.05). The fluid retention amount of treatment group was lesser than the control group(P<0.05). In the aspect of biochemical indicators, the treatment was better than the control group(P<0.05). [Conclusion] Xiaoyan decoction can improve the therapeutic effect, nutritional status, the quality of life and reduce the adverse reactions of the cachexia patients of late malignant tumor.