化瘀通阳方药对UC大鼠L/M值及P选择素影响的观察

Study on the effect of removing stasis and diffusing yang therapy to LMR and P-selectin of ulcerative colitis rats

关键词:  化瘀通阳方  溃疡性结肠炎  乳果糖/甘露醇值  P选择素

Key words:  resolving stasis and diffusing yang therapy  ulcerative colitis  L/M  P-sel

摘要:

[目的]观察化瘀通阳方药对溃疡性结肠炎（UC）大鼠乳果糖/甘露醇值（L/M值）及P-选择素的影响，并探讨二者可能的关系。[方法]采用葡聚糖硫酸钠法进行UC大鼠模型的制作，分别予化瘀通阳方药灌肠及美沙拉嗪灌肠治疗，比较造模及治疗前后乳果糖/甘露醇值（L/M值）及P-选择素。[结果]造模后，大鼠L/M值及P-选择素较造模前明显增高，经化瘀通阳方药灌肠治疗，二者均明显减低，且与美沙拉嗪灌肠组相比，无统计学差异。[结论]化瘀通阳方药可有效降低UC模型大鼠L/M值及P-选择素，且与美沙拉嗪灌肠疗效相当。

Abstract:

[Objective] Observed the effect of removing stasis and diffusing yang therapy to LMR and P-selectin of ulcerative colitis rats, while analysis the relationship between the intestinal permeability and P-selectin level.[Methods] Ulcerative colitis model rats were made by DSS, mesalazine enema liquid and removing stasis and diffusing yang (RSDY) herbs in retention edema. The data of L/M and P-sel level were compared aftermolding and before and fater treatment.[Results] It was obviously found that L/M and P-sel level of the model replication group significantly increased comparing with the data of the normal group. The datas of L/M and P-sel level of the group treated by mesalazine and RSDY herbs was obviously less than the data of the model control group, while there was no significant difference between two groups.[Conclusion] Removing stasis and diffusing yang herbs retention enema can reduce L/M and P-sel level of the ulcerative colitis rats, while there was no statistically significant difference comparing with mesalazine group.