中药肠内营养剂干预代谢综合征的临床观察

Clinical observation on metabolic syndrome of traditional Chinese medicine agent of enteral nutrition intervention

关键词:  中药肠内营养剂  干预  代谢综合征

Key words:  traditional Chinese medicine enteral nutrition agent  intervention  metabolic syndrome

摘要:

[目的] 探讨中药肠内营养剂对代谢综合征（MS）患者的影响。[方法] 将120名MS患者随机分成中药肠内营养剂研究组和西药对照组各60名。西药对照组在给予西医标准化药物治疗同时加强运动及科学的膳食管理。中药肠内营养剂研究组经与对照组相同治疗手段，同时在患者规定的特定主食中辨证加入中药细粉组成的中药肠内营养剂。经过1 a的干预分别观察两组干预前后体质量指数（BMI）、血压、患者空腹血糖（FPG）、餐后2 h血糖（2 h PG）、糖化血红蛋白（HbA1c）、低血糖发生率、血清甘油三酯（TG）、血清总胆固醇（TC）、血清低密度脂蛋白（LDL）、尿微量白蛋白（UmA）、肝肾功能等的变化。[结果] 两组经1 a干预治疗后以上各项观察指标，两组内分别与治疗前比较有统计学差异（P<0.01），研究组与对照组治疗后组间比较也有统计学差异（P<0.05）；肝肾功能、低血糖发生率两组治疗前后比较无统计学差异（P>0.05）.[结论] 加用中药肠内营养剂的研究组经过1 a的干预各项代谢综合征不良指标的改善明显优于单纯的对照组标准化西药药物治疗，并且未见肝肾功能的损害。

Abstract:

[Objective] To study the traditional Chinese medicine agent of enteral nutrition in patients with metabolic syndrome (MS). [Methods] The 120 MS patients were randomly divided into enteral nutrition agent group and western medicine treatment control group with 60 in each. The control group used Western medicine standardization treatment and improved dietary management and sports at the same time. The treatment group added traditional Chinese medicine powder as enteral nutrition agent with syndrome differentiating at the same time with control group. Treatment in patients at the same time prescribed. The change of BMI, blood pressure, fasting blood glucose (FPG), 2 h postprandial blood glucose (2 h PG), glycosylated hemoglobin (HbA1c), the incidence of hypoglycemia, serum triglyceride (TG), serum total cholesterol (TC), serum levels of low-density lipoprotein (LDL), urine trace albumin (UmA), the change of liver and renal function were observed between groups after one year intervention. [Results] Compared with before treatment, each group had significant difference (P<0.01) after one year intervention above indicators. Treatment group compared with control group after treatment had significant difference (P<0.05). In liver and kidney function and the incidence of hypoglycemia between two groups before and after treatment was no significant difference (P>0.05). [Conclusion] The index of treatment group added with traditional Chinese medicine enteral nutrition agent after a year intervention was significantly improved than simple standardized treatment of Western medicine in control group, and no liver and kidney function damaged.