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| 北细辛根化学成分研究 |
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董玉启1,2, 于华1,2, 王春华1,3, 李正1,3, 朱彦1,2
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1.天津中医药大学天津市现代中药重点实验室, 天津 300193;2.天津国际生物医药联合研究院中药新药研发中心, 天津 300457;3.天津中医药大学中药制药工程学院, 天津 300193
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| 摘要: |
| [目的] 研究北细辛根乙醇提取部分的化学成分。[方法] 应用硅胶柱层析、Sephadex LH-20葡聚糖凝胶、制备高效液相等方法分离纯化化合物，并通过核磁共振、质谱等方法对化合物进行结构鉴定。[结果] 从北细辛根二氯甲烷部分分离鉴定了15个化合物，分别为：（1R，2S，5R，6R）-5'-O-methylpluviatilol、咖啡酸甲酯、（2E，4E，8E）-N-isobutyl-2，4，8-decatrienamide、升麻酸、（1S，4S，5S）-5-isopropyl-2-methyl-2-cyclohexene-1，4-diol、（±）-asarinol A、对羟基苯甲醛、3-甲氧基-4-羟基苯甲酸、4-羟基-苯乙醇、对羟基肉桂酸、β-谷甾醇、L-细辛脂素、3，4-亚甲二氧基苯甲酸、卡枯醇和3，4-二甲氧基肉桂醇。[结论] 结果中前10个化合物1~10为首次从北细辛中分离得到。 |
| 关键词: 北细辛 化学成分 结构鉴定 |
| DOI：10.11656/j.issn.1672-1519.2017.12.15 |
| 分类号:R284.1 |
| 基金项目:国家自然科学基金青年项目（81403059），天津市科技特派员项目（16JCTPJC49000）和天津市科技计划项目（14TXZYJC00440）。 |
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| Chemical constituents from the roots of Asarum heterotroprides var. mandshuricum |
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DONG Yu-qi1,2, YU Hua1,2, WANG Chun-hua1,3, LI Zheng1,3, ZHU Yan1,2
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1.Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin 300457, China;3.College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| [Objective] To investigate the chemical constituents from the alcohol fraction of the roots of Asarum heterotroprides var. Mandshuricum.[Methods] Column chromatographies of silica gel, preparative HPLC and Sephadex LH-20 are applied to isolate the chemical constituents. Pure compounds were elucidated by means of 1H NMR, 13C NMR and LC-MS.[Results] Fifteen compounds were isolated and identified as (1R, 2S, 5R, 6R)-5'-O-methylpluviatilol, methyl caffeate, (2E, 4E, 8E)-N-isobutyl-2, 4, 8-decatrienamide, cimicifugic acid, (1S, 4S, 5S)-5-isopropyl-2-methyl-2-cyclohxene-1, 4-diol, (±)-asarinol A, p-hydroxybenzaldehyde, 3-methoxy-4-hydroxybenzoic acid, 4-hydroxyphenethyl alcohol, p-hydroxycinnamic acid, β-sitosterol, L-asarinin, piperonylic acid, kakuol and 3, 4-dimethoxycinnamylic alcohol.[Conclusion] Compounds 1~10 were obtainted from Asarum heterotroprides var. mandshuricum for the first time. |
| Key words: Asarum heterotroprides var.mandshuricum chemical constituent structure elucidation |
