芪冬颐心口服液对急性心肌梗死患者临床疗效及预后的影响

Effects of Qidong Yixin oral liquid on clinical efficacy and prognosis in patients with acute myocardial infarction

关键词:  急性心肌梗死  芪冬颐心口服液  疗效  预后

Key words:  acute myocardial infarction  Qidong Yixin oral liquid  clinical efficacy  prognosis

摘要:

[目的]观察芪冬颐心口服液对急性心肌梗死患者临床疗效及预后的影响。[方法]选取2013年1月-2016年1月重庆市中医院收治的急性心肌梗死患者280例为研究对象，将患者按随机数字表法随机分为对照组（140例）和试验组（140例）。对照组给予常规治疗，试验组在常规治疗的基础上给予芪冬颐心口服液口服半年。观察两组患者治疗后临床疗效，治疗前后炎性指标变化、不良心血管事件（MACE）发生率及心功能情况。[结果]经过相应治疗后，试验组患者总有效率为92.9%，显著高于对照组85.0%，差异有统计学意义（P<0.05）。与治疗前相比，治疗后两组患者炎性指标高敏C反应蛋白（hs-CRP）、白介素-6（IL-6）及肿瘤坏死因子-α（TNF-α）水平显著降低，其中试验组上述炎性指标降低水平明显高于对照组，差异有统计学意义（P<0.05）。随访半年，试验组MACE发生率低于对照组，但差异无统计学意义。与治疗前比较，治疗后两组患者心功能指标左心室舒张末内径（LVEDD）和左心室收缩期内径（LVESD）明显降低，而左心室射血分数（LVEF）明显升高，其中试验组上述心功能指标水平较对照组改善更明显，差异有统计学意义（P<0.05）。[结论]芪冬颐心口服液可显著提高急性心肌梗死患者临床疗效，降低体内炎症水平和改善患者预后，值得临床进一步推广运用。

Abstract:

[Objective] To observe the effect Qidong Yixin oral liquid on clinical efficacy and prognosis in patients with acute myocardial infarction.[Methods] A total of 280 patients with acute myocardial infarction were selected from January 2013 to January 2016, these patients were randomly divided into the control group (140) and the treatment group (140). The control group was given routine therapy, and the treatment group was given Qidong Yixin oral liquid for six months on basis of conventional treatment. The clinical efficacy, inflammatory parameters, adverse cardiovascular events incidence and cardiac function after treatment were observed.[Results] After treatment, the total effective rate was 92.9% in the treatment group, which was significantly higher than that in the control group (85.0%), and the difference was statistically significant (P<0.05). Compared with before treatment, the levels of hs-CRP, IL-6 and TNF-α were significantly decreased in two groups after treatment, and the decreased levels of inflammatory indexes in the treatment group were significantly higher than that in the control group (P<0.05). The incidence of MACE was lower in the treatment group than that in the control group, but the difference was not statistically significant(P>0.05). Compared with before treatment, the cardiac function index including the left ventricular diastolic diameter (LVEDD) and left ventricular systolic diameter (LVESD) were significantly decreased, while the left ventricular ejection fraction (LVFF) was significantly higher after treatment, and the above-mentioned cardiac function index in the treatment group were better than the control group. The difference was statistically significant (P<0.05).[Conclusion] Qidong Yixin oral liquid can significantly improve clinical efficacy in patients with acute myocardial infarction, reduce the inflammation index and improve the prognosis, which is worth further clinical application.