| 摘要: |
| [目的]观察益肾调肝解郁法治疗肝肾阴虚型帕金森病抑郁（PDD）的临床疗效。[方法]将60例肝肾阴虚型PDD患者随机分为治疗组和对照组各30例。治疗组予西药基础治疗+益肾调肝解郁法中药，对照组予西药基础治疗+中药安慰剂，治疗8周。观察17项汉密尔顿抑郁量表（HAMD-17）、统一帕金森病评定量表（UPDRS）Ⅰ、Ⅱ、Ⅲ、Ⅳ 4部分评分及其总分、39项帕金森病生存质量问卷（PDQ-39）评分变化。[结果]治疗后，治疗组HAMD-17、PDQ-39、UPDRS各部分评分及UPDRS总分均较治疗前降低（P<0.05），且治疗组的各量表评分均明显低于对照组（P<0.05）。[结论]益肾调肝解郁法能有效改善肝肾阴虚型PDD患者的运动症状和抑郁症状，使患者生活质量进一步提高，值得推广应用。 |
| 关键词: 帕金森病抑郁 益肾调肝解郁法 临床研究 |
| DOI：10.11656/j.issn.1672-1519.2018.01.04 |
| 分类号:R277.7 |
| 基金项目:广西中医药大学研究生教育创新计划项目（YJS201637）；广西壮族自治区临床重点专科建设项目[桂卫医发（2015）5号]。 |
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| Clinical study on Parkinson's disease with depression with yin deficiency of liver and kidney by the therapy of Yishen Tiaogan Jieyu |
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MO Haizhen,HU Yuying,LIANG Huihui,LIU Xiaoxiong
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The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
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| Abstract: |
| [Objective] To observe the curative effect on the therapy of Yishen Tiaogan Jieyu on Parkinson's disease with depression (PDD) with yin deficiency of liver and kidney.[Methods] A total of 60 cases of PDD patients were randomly divided into the treatment group and the control group,30 cases in each group. The treatment group was given the combination of Bushen Zhichan decoction and Xiaoyao powder and the basic treatment of Western medicine, while the control group was given the placebo and the basic treatment of western medicine, and the treatment course lasted for 8 months. The scores of 17-item Hamilton Depression Rating Scale(HAMD-17), the unified Parkinson Disease Rating Scale (UPDRS),Ⅰ,Ⅱ, Ⅲ,Ⅳ 4 parts and its total score and the 39-item Parkinson's Disease Questionnaire (PDQ-39) were evaluated respectively before treatment and after treatment.[Results] After treatment,the scores of HAMD-17, PDQ-39, each part of UPDRS and its total in the treatment group lower than those before(P<0.05), and the score of each scale in the treatment group were significantly lower than those in the control group (P<0.05).[Conclusion] The therapy of Yishen Tiaogan Jieyu could effectively improve the motor symptoms and depressive symptoms in patients with PDD with yin deficiency of liver and kidney, and further improve the quality of life of patients, it is worthy of popularization and application. |
| Key words: Parkinson's disease with depression the therapy of Yishen Tiaogan Jieyu clinical study |
