AMPK在保护血管功能中研究进展

Research progress of AMPK in protecting vascular function

关键词:  AMPK  血管功能  中医药

Key words:  AMPK  vascular function  traditional Chinese medicine

摘要:

腺苷酸活化蛋白激酶（AMPK）是一种丝氨酸/苏氨酸蛋白激酶，它是细胞内能量感受器并且参与了细胞和全身器官的能量代谢调节。AMPK的激活有许多潜在的抗动脉粥样硬化的效果，包括减少炎症细胞黏附在内皮上，减少脂质氧化引起的脂质累计和炎症细胞的增殖，刺激细胞抗氧化保护的基因表达和一氧化氮形成的酶。除了用于心血管和代谢性疾病的药物如他汀类，二甲双胍和噻唑烷二酮类之外，中医药宝库中也有许多涉及了AMPK的激活。总的来说，AMPK的激活与维护血管健康有密不可分的关系。综述了AMPK在保护血管功能中作用及机制的研究进展。

Abstract:

Adenosine monophosphate-activated protein kinase (AMPK) is a serine/threonine protein kinase and sensor of cellular energy status,which involved in the regulation of cellular and whole organ metabolism. Activation of AMPK has a number of potentially beneficial antiatherosclerotic effects including reducing adhesion of inflammatory cells to the blood vessel endothelium, reducing lipid accumulation and the proliferation of inflammatory cells caused by oxidised lipids, stimulation of gene expression responsible for cellular antioxidant defenses and stimulation of enzymes responsible for nitric oxide formation. In addition to drugs commonly used in cardiovascular and metabolic disease, such as statins, metformin and the TZDs, many of the TCM also involve the activation of AMPK. In general, the activation of AMPK is closely related to the maintenance of vascular health. This paper reviews the research progress of the role and mechanism of AMPK in the protection of vascular function.