| 摘要: |
| [目的]通过对照定悸方联合常规西医治疗与西医基础治疗干预阵发性房颤气阴两虚证患者，评价定悸方抑制阵发性房颤炎症因子表达及干预心肌纤维化的临床疗效。[方法]按照纳入标准纳入60例患者，随机分为治疗组与对照组，比较治疗前后患者复发情况、发作次数、中医证候改善情况、C-反应蛋白（hs-CRP）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、左房内径、左心射血分数（LVEF）、左室短轴缩短分数（FS）的差别。[结果]经治后，治疗组临床症状改善率高于对照组，差异有统计学意义（P<0.01）；两组患者血清hsCRP、IL-6均显著低于治疗前（P<0.05），且治疗组血清hs-CRP、IL-6均低于对照组（P<0.05）；随访半年后，两组LVEF、FS值均比治疗前显著升高（P<0.05），且治疗组LVEF值较对照组升高更为明显（P<0.05），治疗组左房内径较治疗前有明显减小趋势（P<0.05）。[结论]定悸方能有效抑制炎症因子过度表达，并具改善心肌纤维化与房室重构的作用。 |
| 关键词: 阵发性房颤 炎症因子 心肌纤维化 定悸方 |
| DOI：10.11656/j.issn.1672-1519.2018.06.03 |
| 分类号:R541.75 |
| 基金项目:国家自然科学基金资助项目（81603594）；上海市中医药发展三年行动计划-传统中医科建设项目（ZYSNXDYL-CTXK）；第三批全国优秀中医临床人才中医药管理局培养项目；上海市卫生和计划生育委员会科研课题（201740151）。 |
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| Observation on the inhibition of inflammatory cytokines and the intervention of myocardial fibrosis by Dingjifang recipe |
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HUANG Yao, ZHANG Zhenxian, CHEN Ruohong, DING Yueyi, CHEN min
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Chinese Medicine Internal Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
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| Abstract: |
| [Objective] To observe the inhibition of inflammatory cytokines and the intervention of myocardial fibrosis in qi and yin deficiency synclrome patients with paroxysmal atrial fibrillation between Dingjifang recipe group and Western medicine group.[Methods] The 60 patients, according to the inclusion criteria, randomly divided into for treatment group and control group, compared the difference between two groups before and after treatment, including attack frequency, traditional Chinese medicine symptoms, high-sensitivity CRP (hsCRP), interleukin 6 (IL-6) and tumor necrosis factor-α(TNF-α), left atrial diameter, left ventricular ejection fraction (LVEF) and left ventricular short axis fractional shortening (FS).[Results] After treatment, the clinical symptom improvement rate of treatment recipe group was higher than that of control group. The difference was statistically significant (P<0.01). The serum hsCRP and IL-6 of patients in two groups were significantly lower than before treatment (P<0.05), and the serum levels of hsCRP and IL-6 in treatment group were lower than in the control group (P<0.05). Patients followed up for six months, LVEF, FS values in two groups were higher than that before treatment(P<0.05), and the LVEF increased more significantly in treatment group than control group (P<0.05), the left atrial diameter of treatment group was significantly decreased after treatment (P<0.05).[Conclusion] Dingjifang recipe can effectively inhibit the over expression of inflammatory factors and improve myocardial fibrosis and ventricular remodeling. |
| Key words: paroxysmal atrial fibrillation inflammatory cytokines myocardial fibrosis Dingjifang recipe |
