血府逐瘀汤对血瘀体质冠心病合并高脂血症患者血清炎症因子、内皮功能及心血管事件的影响

Effect on serum inflammatory factors,endothelial function and cardiovascular events of Xuefu Zhuyu decoction in coronary heart disease complicated with hyperlipidemia patients with blood stasis constitution

关键词:  血府逐瘀汤  冠心病  高脂血症  血瘀体质  炎症因子  内皮功能  心血管事件

Key words:  Xuefu Zhuyu decoction  coronary heart disease  hyperlipidemia  blood stasis constitution  inflammatory factor  endothelial function  cardiovascular event

摘要:

[目的]观察血府逐瘀汤对血瘀体质冠心病合并高脂血症患者血清炎症因子、内皮功能及心血管事件的影响。[方法]将125例血瘀体质冠心病合并高脂血症患者随机分为观察组（64例）和对照组（61例）。对照组给予常规西医治疗，观察组在对照组的基础上给予血府逐瘀汤治疗2个月。6个月后，观察两组患者血清炎症因子、内皮功能指标及心血管事件发生情况。[结果]1）两组白介素（IL）-1β、IL-18、超敏C-反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）水平比较差异有统计学意义（P<0.05），两组IL-1β、IL-18、hs-CRP、TNF-α随着时间的延长呈逐渐下降的趋势（P<0.05），观察组下降幅度大于对照组（P<0.05）。2）两组一氧化氮（NO）、6-酮-前列腺素F-1α（6-Keto-PGF-1α）、内皮素-1（ET-1）、血栓素B2（TAXB2）水平比较差异有统计学意义（P<0.05），两组NO、6-Keto-PGF-1α随着时间的延长呈逐渐升高趋势，而ET-1、TAXB2呈逐渐下降的趋势（P<0.05），观察组变化幅度大于对照组（P<0.05）。3）观察组心血管事件总发生率为7.81%，对照组总发生率为22.95%，两组总发生率比较差异有统计学意义（P<0.05）。[结论]血府逐瘀汤应用于血瘀体质冠心病合并高脂血症患者，有抑制炎症反应、保护内皮功能的作用，有助于降低心血管事件发生风险。

Abstract:

[Objective] To observe the effect on serum inflammatory factors,endothelial function and cardiovascular events of Xuefu Zhuyu decoction in coronary heart disease complicated with hyperlipidemia patients with blood stasis constitution.[Methods] The 125 cases of coronary heart disease complicated with hyperlipidemia patients with blood stasis constitution were randomly divided into the observation group (64cases)and the control group(61 cases). The control group was given conventional therapy, and the observation group was given Xuefu Zhuyu decoction for 2 months based on conventional therapy. For 6 months, the changes of serum inflammatory factors, endothelial function and cardiovascular events were observed between the two groups.[Results] 1)There was significantly difference of IL-1β,IL-18,hs-CRP,TNF-α in these two groups (P<0.05). All indexes of the two groups were showed a declining trend over time (P<0.05), the changed amplitude in observation group was higher than the control group (P<0.05). 2)There was significantly difference of NO,6Keto-PGF-1α, ET-1,TAXB2 in these two groups (P<0.05), the two groups of NO,6-Keto-PGF-1a were showed a rising trend over time and ET-1,TAXB2 were showed a declining trend over time (P<0.05), the changed amplitude in observation group was higher than the control group (P<0.05). 3) In the observation group, the total incidence rate cardiovascular events group was 7.81%, and that of the control group was 22.95%, with significant difference (P<0.05).[Conclusion] Xuefu Zhuyu decoction can inhibit inflammation, protect endothelial function and reduce the occurrence of cardiovascular events in coronary heart disease complicated with hyperlipidemia patients with blood stasis constitution.