| 摘要: |
| [目的]探讨三七总皂苷（PNS）联用胺碘酮对阵发性房颤（PAF）患者左心房内径（LAD）和心锚重复蛋白（CARP）的影响。[方法]将70例PAF患者随机分为治疗组35例（PNS联用胺碘酮）与对照组35例（单用胺碘酮）。随访6个月，观察复发情况、测定治疗前及治疗6个月后LAD及CARP水平。[结果]在治疗6个月后，治疗组窦性心律维持率显著高于对照组（P<0.05）；治疗组LAD明显低于对照组（P<0.05）；治疗组CARP水平明显低于对照组（P<0.05）。[结论]PNS联用胺碘酮较单用胺碘酮可明显减少房颤复发，降低PAF患者LAD和CARP水平。 |
| 关键词: 三七总皂苷 胺碘酮 阵发性心房颤动 左心房内径 心锚重复蛋白 |
| DOI：10.11656/j.issn.1672-1519.2018.08.04 |
| 分类号:R541 |
| 基金项目:深圳市龙岗区科技计划医疗卫生项目（YS2013100）；深圳市三名工程-中国医学科学院阜外医院心血管病张建团队。 |
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| Effect of panax notoginsenosides plus amiodarone on left atrial diameter and cardiac ankyrin repeat protein in patients with paroxysmal atrial fibrillation |
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KUANG Rongren1, YUAN Liping2, HE Xianzhi3, ZHANG Zhong1
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1.Shenzhen Tiaditional Chinese Medicine Hospital, Shenzhen 518033, China;2.Longgang Central Hospital of Guangdong Province, Shenzhen 518116, China;3.The People's Hospital of Guangdong Zhuhai, Zhuhai 519000, China
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| Abstract: |
| [Objective] To discuss the effect of panax notoginsenosides (PNS) or plus amiodarone on left atrial diameter (LAD) and cardiac ankyrin repeat protein(CARP) in patients with paroxysmal atrial fibrillation(PAF).[Methods] Seventy PAF patients were randomized into PNS plus amiodarone group (35 cases) and amiodarone group (35 cases). The rate of sinus rhythm maintenance, LAD and CARP were observed within 6 months of follow-up.[Results] It's demonstrated that the rate of sinus rhythm maintenance in PNS plus amiodarone group was significantly higher than that in amiodarone group (P<0.05). LAD in PNS plus amiodarone group was significantly lower than that in amiodarone group (P<0.05). CRAP in PNS plus amiodarone group was significantly lower than that in amiodarone group (P<0.05).[Conclusion] Compared to amiodarone alone, PNS plus amiodarone can significantly reduce AF recurrence, LAD and CARP in PAF patients. |
| Key words: panax notoginsenosides amiodarone paroxysmal atrial fibrillation left atrial diameter cardiac ankyrin repeat protein |
