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| 水蛭的化学成分研究 |
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李国强1, 李韵仪1, 李桃2, 李药兰2, 王国才2, 王春华3, 李正3
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1.佛山科学技术学院, 食品科学与工程学院, 佛山 528000;2.暨南大学药学院, 广州 510632;3.天津中医药大学中药制药工程学院, 天津 300193
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| 摘要: |
| [目的]研究中药水蛭的化学成分。[方法]采用硅胶柱层析、Sephadex LH-20等色谱方法进行分离纯化，依据理化性质及波谱数据进行结构鉴定。[结果]从中药水蛭的95%乙醇提取物中分离得到9个化合物，分别鉴定为：吲哚-3-甲酸-β-D-吡喃葡萄糖苷（1）、3-吲哚-甲醛（2）、腺苷（3）、2-羟基嘌呤核苷（4）、尿嘧啶核苷（5）、腺嘌呤（6）、尿嘧啶（7）、黄嘌呤（8）和2-哌啶酮（9）。[结论]首次从该药材中分离得到9种化合物。 |
| 关键词: 水蛭 化学成分 结构鉴定 |
| DOI：10.11656/j.issn.1672-1519.2018.09.17 |
| 分类号: |
| 基金项目:天津市科委科研计划项目（2017KJ138）；天津市科技计划项目（15PTCYSY00030）。 |
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| Chemical constituents from Whitmania pigra |
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LI Guoqiang1, LI Yunyi1, LI Tao2, LI Yaolan2, WANG Guocai2, WANG Chunhua3, LI Zheng3
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1.College of Food Science and Engineering, Foshan University, Foshan 528000, China;2.College of Pharmacy, Jinan University, Guangzhou 510632, China;3.College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| [Objective] Investigate the chemical constituents of Whitmania pigra.[Methods] Various column chromatographic methods including silica gel and Sephadex LH-20 were used for the isolation and purification. Chemical structures were elucidated on the basis of spectroscopic analysis.[Results] Nine compounds were isolated and identified as indole-3-carboxylic acid-β-D-glucopyranosyl (1), indole-3-carboxaldehyde (2), adenosine (3), 2-hydroxypurine nucleoside (4), uridine (5), adenine (6), uracil (7), xanthine (8), 2-piperidinone (9).[Conclusion] All the compounds are isolated from Whitmania pigra for the first time. |
| Key words: Whitmania pigra chemical constituent structure identification |
