穴位贴敷治疗2型糖尿病胃轻瘫所致便秘的随机对照研究

A randomized controlled study of type 2 diabetic gastropareses constipation by acupoint application therapy

关键词:  穴位贴敷  2型糖尿病胃轻瘫  便秘  随机对照研究

Key words:  acupoint application therapy  type 2 diabetic gastroparesis  constipation  randomized controlled study

摘要:

[目的]观察中药穴位贴敷治疗2型糖尿病胃轻瘫便秘的疗效和安全性。[方法]运用随机数字表法将84例符合纳入标准的2型糖尿病胃轻瘫便秘患者随机分为试验组（42例）和对照组（42例）。两组在控制血糖基础上，治疗组采用中药穴位贴敷治疗；对照组口服麻仁软胶囊，治疗4周，观察两组治疗前后便秘症状积分（CSI）、便秘患者生存质量自评量表（PAC-QOL）总分及糖化血清蛋白和安全性指标。[结果]试验组治疗后CSI（4.13±1.95）分、PAC-QOL总分（34.88±16.90）分和糖化血清蛋白（2.09±0.29）mmol/L分别优于治疗前CSI（8.38±1.53）分、PAC-QOL总分（58.18±21.65）分和糖化血清蛋白（2.28±0.37）mmol/L；对照组治疗后CSI（5.63±2.32）分、PAC-QOL总分（45.29±19.66）分和糖化血清蛋白（2.19±0.37）mmol/L分别优于治疗前CSI（8.02±2.01）分、PAC-QOL总分（55.00±22.05）分和糖化血清蛋白（2.26±0.39）mmol/L；差异具有统计学意义（P<0.05）；试验组在CSI（4.13±1.95）分、PAC-QOL总分（34.88±16.90）分，分别优于对照组CSI（5.63±2.32）分、PAC-QOL总分（45.29±19.66）分，差异具有统计学意义（P<0.05）；试验组和对照组在糖化血清蛋白比较无统计学差异。两组均无不良事件报告。[结论]中药穴位贴敷治疗2型糖尿病胃轻瘫便秘可以改善患者症状、生活质量和糖化血清蛋白，安全可靠，为临床治疗2型糖尿病胃轻瘫便秘提供一种简便有效的中医技术。

Abstract:

[Objective] To evaluate the clinical curative effect and safety of acupoint application therapy on the constipation due to type 2 diabetic gastroparesis (DGP).[Methods] The 84 patients of eligible the inclusion criteria were randomly divided into treatment group (42 cases) and control group (42 cases). Based on the control of blood glucose, the treatment group was treated by acupoint application therapy while the control group treated by oral Ma Ren Ruan Capsule (MRRC) for 4 weeks. The Constipation Symptom Integral(CSI), the Patient Assessment of Constipation Quality of Life (PAC-QOL), Glycosylated serum protein(GSP), and Security Indexes were observed before and after the treatment of both groups.[Results] The CSI (4.13±1.95) vs (8.38±1.53), PAC-QO (34.88±16.90) vs (58.18±21.65) and GSP (2.09±0.29) mmol/L vs (2.28±0.37) mmol/L of the Experimental group after treatment were better than before; The CSI (5.63±2.32) vs (8.02±2.01), PAC-QOL (45.29±19.66) vs (55.00±22.05) and GSP(2.19±0.37) mmol/L vs(2.26±0.39) mmol/L of the Control group after treatment were better than before. Both differences were statistically significant (P<0.05). After treatment, the Experimental group was better than the control group of CSI[(4.13±1.95) vs (8.38±1.53)] and PAC-QOL[(34.88±16.90) vs (45.29±19.66)], which had significant statistical difference (P<0.05); There was no statistical difference between the experimental group and the control group in GSP[(2.09±0.29) mmol/L vs (2.19±0.37) mmol/L]. No adverse events were reported in both groups.[Conclusion] It is effective and safe that the constipation due to 2 diabetic gastropareses treated by acupoint application therapy. Acupoint application therapy with traditional Chinese medicine (TCM) provide a simple and effective treatment for the constipation due to 2 diabetic gastropareses.