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基于复杂系统熵聚类方法探讨血脂异常治疗药物组合特征的文献研究
李鑫, 薛晓琳, 周子严, 葛肖波, 王亦成
北京中医药大学, 北京 100029
摘要:
[目的]基于复杂系统熵聚类方法探讨血脂异常治疗药物组合特征。[方法]通过检索中国知网(CNKI)、中文科技期刊全文数据库(VIP)、万方数据库中近10年有关血脂异常的文献,对符合纳排标准的文献所涉及到的药物进行提取、统计和分析。[结果]纳入研究的文献中,使用频次较高的药物依次为山楂、丹参、泽泻、茯苓、何首乌等;基于熵聚类算法挖掘出10组治疗血脂异常的常用药物组合。[结论]药物组合的特征反映出血脂异常用药的基本原则是益气健脾、燥湿化痰、活血化瘀,而调理肝肾的用药思路在血脂异常的治疗中也占有重要地位。
关键词:  血脂异常  复杂系统熵聚类  药物组合特征  文献研究
DOI:10.11656/j.issn.1672-1519.2018.11.08
分类号:R589.2
基金项目:北京市东城区课题中医药特色健康管理项目(2180072120002)。
A literature study on the characteristics of blood lipids, based on a sophisticated system entropy clustering method
LI Xin, XUE Xiaolin, ZHOU Ziyan, GE Xiaobo, WANG Yicheng
Beijing University of Chinese Medicine, Beijing 100029, China
Abstract:
[Objective] To explore the characteristics of drug combination of blood lipid abnormality based on the complex system entropy clustering method.[Methods] The extraction, statistics and analysis of the drugs involved in the literature concerning the inclusion criteria were obtained by retrieving the literatures about the abnormal blood lipids in Chinese journal full text database (CNKI),Chinese science and technology periodical full-text database(VIP),Wanfang database for nearly 10 years.[Results] Among the literatures included in the study, the higher frequency of the drugs were Hawthorn, Salvia miltiorrhiza, Oriental waterplantain tuber, Indian buead, Tuber fleeceflower root, etc. Based on the entropy clustering algorithm, ten groups of commonly used drug combinations were found to treat the abnormal blood lipids.[Conclusion] The characteristics of the combination of drugs reflect the basic principles of the treatment of abnormal blood lipids, such as invigorating qi, invigorating the spleen, drying and removing phlegm, and activating blood circulation and removing blood stasis, while the thought of supplementing liver and kidney is also important in the treatment of dysplasia.
Key words:  dyslipidemia  entropy clustering of complex system  drug combination characteristics  literature research
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