眼底激光联合中药菩人丹治疗糖尿病视网膜病变的临床观察

Clinical observation of fundus laser combined with Puren Dan in treating diabetic retinopathy

关键词:  眼底激光  菩人丹  糖尿病  视网膜病变  临床观察

Key words:  fundus laser  Puren Dan  diabetes  retinopathy  clinical observation

摘要:

[目的] 评价氪黄激光视网膜光凝术联合中药菩人丹对重度非增殖性糖尿病性视网膜病变（NPDR）治疗的临床疗效。[方法] 选取NPDR患者70例，随机分为两组，每组35例（70只眼），治疗组给予视网膜光凝联合中药菩人丹口服；对照组给予视网膜光凝联合羟苯磺酸钙分散片口服。均连续服药3个月，观察治疗前后视力、荧光素眼底血管造影、血液流变学、中医证候疗效等检查结果，并进行组间对比，以评价其疗效。[结果] 1）对于视力改善，两组视力治疗前后均有明显改善，有统计学意义（P<0.05）；治疗后两组间对比，治疗组优于对照组，两组差异有统计学意义（P<0.05）。2）对于眼底照相、荧光素眼底血管造影，两组治疗前后微血管瘤、出血、棉绒斑等均有明显改善，前后对比有统计学意义（P<0.05），治疗后两组间对比差异无统计学意义（P>0.05）。3）对于血液流变学的检测，治疗组及对照组均有改善，用药前后全血黏度、血沉、全血还原黏度均降低，前后有统计学意义（P<0.05），用药前后的红细胞变形指数升高（F=14.1，P=0.006），治疗组与对照组用药前后血液流变学各项指标差异有统计学意义（P<0.05）。4）中医证候疗效，治疗后两组间进行比较，治疗组明显优于对照组，差异有统计学意义（P<0.05）。[结论] 视网膜光凝联合中药菩人丹治疗重度NPDR临床疗效确切。

Abstract:

[Objective] Evaluation of krypton laser photocoagulation combined with traditional Chinese medicine Puren Dan on severe non proliferative diabetic retinopathy (NPDR) clinical curative effect.[Methods] Using randomized controlled methods, 70 patients with NPDR were selected, randomly divided into two groups, each group of 35 people (70 eyes). The treatment group was treated with photocoagulation combined with traditional Chinese medicine Puren Dan oral; control group received photocoagulation combined with calcium dobesilate dispersible tablets. All patients were treated for 3 months. Visual acuity, fundus fluorescein angiography, hemorrheology and traditional Chinese medicine (TCM) symptoms were observed before and after treatment.[Results] 1)The improvement of visual acuity, visual acuity of two groups before and after treatment were significantly improved, with statistical significance (P<0.05); after treatment between the two groups, the treatment group than the control group, there was significant difference between two groups (P<0.05). 2)For fundus photography, fundus fluorescein angiography, two groups before and after treatment of microaneurysm, hemorrhage, cotton wool spots were improved significantly, there was statistical significance before and after contrast (P<0.05), after treatment between the two groups was not statistically significant (P>0.05). 3)For the detection of blood rheology, treatment group and control group were improved after treatment, whole blood viscosity, erythrocyte sedimentation rate, blood viscosity decreased, and there was statistical significance (P<0.05) before and after treatment, the erythrocyte deformation index increased (F=14.1, P=0.006), the treatment group and control group before and after treatment the indexes of blood rheology were statistically significant(P<0.05). 4)The curative effect of TCM syndrome was compared between the two groups after treatment. The treatment group was obviously better than the control group. The difference was statistically significant. (P<0.05).[Conclusion] Photocoagulation combined with traditional Chinese medicine Puren Dan clinical curative effect in treatment of severe NPDR exactly.