| 摘要: |
| [目的]探索全蝎蜈蚣颗粒剂治疗难治性哮喘的临床疗效。[方法]78例难治性哮喘患者被随机分为对照组和治疗组。两组患者均给予沙美特罗/氟替卡松吸入治疗，对照组再给予噻托溴铵吸入，治疗组则给予全蝎蜈蚣中药颗粒剂治疗，共计12周。观察治疗前后两组哮喘控制测试（ACT）、肺功能、短效缓解药物用量、呼出气一氧化氮浓度（FeNO）以及血常规、肝肾功能等安全性指标。[结果]治疗后两组ACT评分升高、短效药物使用量减少，FeNO浓度下降，治疗组改善程度明显优于对照组（P<0.05）。两组治疗后肺功能也较治疗前改善，但两组间无统计学差异（P>0.05）。两组治疗后各项安全性指标均在正常范围内。[结论]全蝎蜈蚣中药颗粒剂（每日3 g，连续12周）治疗难治性哮喘可改善临床症状和肺功能，减轻气道炎症，且未发现不良反应。 |
| 关键词: 难治性哮喘 全蝎 蜈蚣 |
| DOI：10.11656/j.issn.1672-1519.2019.04.11 |
| 分类号:R562.25 |
| 基金项目: |
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| Clinical efficacy of scorpion and centipede granule in the treatment of refractory asthma |
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TANG Binqing1, SHI Kehua1, FANG Hong2, WU Yingen2
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1.Department of Respiratory Medicine, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China;2.Prevention and Health Care Department of Traditional Chinese Medicine, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
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| Abstract: |
| [Objective] To study the Clinical efficacy of scorpion and centipede granule in the treatment of refractory asthma.[Methods] The 78 patients with refractory asthma were randomly assigned to the control and treatment groups. Both groups were treated with amitol/fluticasone inhalation,the control group were given tiotropium bromide inhalation in addition,while the treatment group were given scorpion and centipede Chinese medicine granule. Both groups were treated for 12 weeks. Asthma control test (ACT),lung function,short-term remission drug dosage,exhaled nitric oxide concentration (FeNO)and safety indicators such as blood test and liver and kidney function in the two groups were observed before and after treatment.[Results] After treatment,ACT score increased,short-acting drug use decreased,and FeNO concentration decreased in both two groups. But the improvement degree of the treatment group was significantly better than the control group (P<0.05). Lung function was also improved after treatment in the two groups,but there was no significant difference between the two groups (P>0.05). All the safety indicators were in the normal range after treatment in both groups.[Conclusion] Treatment of refractory asthma with scorpion and centipede granule (3g/day,for 12 weeks) can improve clinical symptoms and lung function,reduce airway inflammation,and has no toxic and side effects. |
| Key words: refractory asthma scorpion centipede |
