| 摘要: |
| [目的]利用数据挖掘技术分析干燥综合征的用药规律，为临床辨治决策提供依据。[方法]收集近20多年现代医家治疗干燥综合征的医案文献，采用频数统计分析和关联分析方法，在对现代医家医案按证型分类基础上进行关联分析，探讨治疗干燥综合征的用药规律。[结果]阴虚津亏型中北沙参、麦门冬、生地、石斛、玄参之间存在着明显的用药配伍规律，气阴两虚型中生地、玄参、北沙参、玉竹、麦门冬、生黄芪之间存在着明显的用药配伍规律，阴虚血瘀型中桃仁、红花、生地、白芍、麦门冬、石斛、玄参、当归之间存在着明显的用药配伍规律，肝肾阴虚型中北沙参、麦门冬、生地、生甘草、山茱萸、生山药之间存在着明显的用药配伍规律。[结论]通过数据挖掘方法，可以探明干燥综合征文献中用药组方规律，为临床决策提供依据，也为进一步中医标准化研究提供线索。 |
| 关键词: 干燥综合征 文献 数据挖掘 关联分析 |
| DOI：10.11656/j.issn.1672-1519.2019.04.16 |
| 分类号:R593 |
| 基金项目:天津市科技计划项目（15ZXLCSY00020）；国家中医药管理局中医药标准化项目（SATCM-2015-BZ269）。 |
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| Study on prescription based association analysis of Sjogren's syndrome based on literature |
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LYU Yinghua1,2, WANG Chaoxu3, LIU Wei4, WU Yuanhao4
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1.Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.Traditional Chinese Medicine Department, Xincheng Community Health Service Center in Binhai New Area, Tianjin 300450, China;3.Traditional Chinese Medicine department, Xiangyang Community Health Service Center in Binhai New Area, Tianjin 300451, China;4.Department of Rheumatology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| [Objective] Using data mining technology to analyze the medication rule of Sjogren's syndrome,so as to provide evidence for clinical decision making.[Methods] The literature of the medical case of Sjogren's syndrome was collected over the past 20 years. The frequency statistical analysis and correlation analysis were used to analyze the rule of prescription use in the dry syndrome on the basis of the classification of medical cases according to the type of syndrome.[Results] There are obvious rules of drug compatibility between radix Astragalus,radix Ophiopogon,radix rehmanniae,Dendrobium,and radix sophiae in the qi and yin deficiency type. There are obvious rules of compatibility between radix rehmanniae,radix Astragali,radix Adenophorae,polygonatum odoratum,Ophiopogon japonicus and Astragalus membranaceus. There are obvious rules of compatibility between peach kernel,safflower,radix rehmanniae,radix Paeoniae Alba,radix Ophiopogon,Dendrobium,radix et sogoniae and Angelica in yin deficiency and blood stasis type. There are obvious rules of compatibility between radix et Rhizoma,radix et Rhizoma,radix Ophiopogon,radix rehmanniae,licorice,Cornus officinalis and Rhizoma Dioscorea in liver and kidney yin deficiency type.[Conclusion] Through the method of data mining,it is possible to explore the rule of prescriptions in the literature of Sjogren syndrome,provide the basis for clinical decision,and provide clues for further research on standardization of traditional Chinese medicine. |
| Key words: Sjogren's syndrome literature data mining association analysis |
