宁脉安神颗粒配合缬沙坦治疗伴焦虑状态的女性更年期高血压患者疗效观察

Observation on the curative effects of Ningmai Anshen Granules combined with Valsartan in the treatment of female climacteric hypertension patients with anxiety

关键词:  宁脉安神颗粒  缬沙坦  更年期高血压  焦虑状态

Key words:  Ningmai Anshen Granule  Valsartan  menopausal hypertension  anxious state

摘要:

[目的]观察宁脉安神颗粒配合缬沙坦治疗伴焦虑状态的女性更年期高血压患者的疗效。[方法]纳入伴焦虑状态的女性更年期高血压患者78例，采用随机数字表法随机分为治疗组39例和对照组39例。对照组口服降压药缬沙坦80 mg/d，治疗组在此基础上加服宁脉安神颗粒1袋，早晚各服1次，共8周。两组治疗前后均进行血压监测，汉密尔顿焦虑量表（HAMA）评分，检测超敏C反应蛋白（hs-CRP）和血清肿瘤坏死因子-α（TNF-α），比较治疗前后两组的差异。[结果]治疗8周后，治疗组血压下降幅度优于对照组，差异有统计学意义（P<0.05）。治疗组HAMA积分改善优于对照组（P<0.05）。hs-CRP和TNF-α的改善治疗组优于对照组（P<0.05）。[结论]宁脉安神颗粒有利于提高伴焦虑状态女性更年期高血压患者的治疗效果，改善焦虑状态，降低炎症指标，与单用西药相比有一定优势。

Abstract:

[Objective] To observe the effects of Ningmai Anshen Granules combined with Valsartan in the treatment of menopausal hypertension patients with anxiety.[Methods] The 78 cases of female climacteric hypertension with anxiety in our hospital were randomly divided into treatment group (39 cases) and control group (39 cases) by random number table method. The control group took the antihypertensive drug Valsartan 80 mg everyday orally,and the treatment group took a bag of Ningmai Anshen Granules once in the morning and the evening for a total of 8 weeks beside Valsartan. Blood pressure monitoring and HAMA scores were performed before and after the treatment in both groups,and hs-CRP and TNF-α were detected. The differences between the two groups before and after treatment were compared.[Results] After 8 weeks of treatment,the blood pressure drop in the treatment group was batter than that in the control group (P<0.05). HAMA scores improvement in the treatment group were better than that in the control group (P<0.05). Hs-CRP and TNF-α in the treatment group were batter than that in the control group (P<0.05).[Conclusion] Ningmai Anshen Granules can improve the curative effects and anxiety symptoms of female menopausal hypertension patients with anxiety state,which has certain advantages over western medicine alone.