备孕期青年女性桥本氏甲状腺炎气郁质、25（OH）D3与甲状腺自身抗体的相关性研究

Study on the correlation between Qiyu constitution,25(OH)D3 and thyroid autoantibodies in young women with Hashimoto's thyroiditis during pregnancy

关键词:  桥本氏甲状腺炎  气郁体质  25(OH)D₃  甲状腺自身抗体

Key words:  Hashimoto's thyroiditis  Qiyu constitution  25(OH)D₃  thyroid autoantibody

摘要:

[目的]观察处于备孕期的青年女性桥本氏甲状腺炎（HT）患者不同体质人群中甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TGAb）与25-羟基维生素D₃[25（OH）D₃]水平的差异，并探讨体质因素、25（OH）D₃与甲状腺自身抗体的相关性。[方法]选取甲状腺自身抗体阳性、甲状腺功能正常的处于备孕期的青年女性HT患者共160例，筛出气郁体质组和平和质组，检测其血清激离三碘甲腺原氨酶（FT₃）、游离四碘甲腺原氨酸（FT₄）、促甲状腺激素（TSH）、TPOAb、TGAb以及25（OH）D₃水平。[结果]两组患者FT₃、FT₄、TSH水平无统计学差异（P>0.05），气郁体质组患者的TPOAb、TGAb水平明显高于平和体质组，25（OH）D₃水平低于平和体质组，差异均具有统计学意义P<0.05。[结论]HT患者存在25（OH）D₃缺乏，气郁体质组患者更明显，气郁体质组患者甲状腺自身抗体的水平明显高于平和质组，显示体质因素和25（OH）D₃水平与HT免疫损伤相关。

Abstract:

[Objective] To observe the difference of thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb) and 25(OH)D₃ levels in different constitutional groups of young women with Hashimoto's thyroiditis (HT) during pregnancy preparation,and to explore the correlation between physical factors,25(OH)D₃ and thyroid autoantibody.[Method] The 160 young women with Hashimoto's thyroiditis who had positive thyroid autoantibodies and normal thyroid function during pregnancy were selected to screen out Qiyu constitution group and pinghe constitution group. Their serum levels of FT₃,FT₄,TSH,TPOAb,TGAb and 25(OH)D₃ were detected.[Results] There was no significant difference in FT₃,FT₄ and TSH levels between the two groups (P>0.05). The levels of thyroid autoantibodies (TPOAb,TGAb) in Qiyu constitution group were significantly higher than those in Pinghe constitution group,and 25(OH)D₃ levels were lower than those in Pinghe constitution group. The difference between the two groups was statistically significant (P<0.05).[Conclusion] HT patients had a 25(OH)D₃ deficiency,especially in Qiyu constitution group. The level of thyroid autoantibodies in Qiyu constitution group is significantly higher than that in Pinghe constitution group. It shows that the level of constitutional factors and 25(OH)D₃ is related to the immune damage of Hashimoto thyroiditis.