| 摘要: |
| 中国肿瘤患者中，胃癌的发病率及病死率均较高。胃癌前病变（PLGC）是胃癌发展的关键阶段，及时诊断、干预PLGC，可降低胃癌发生发展风险。PLGC的治疗，西医目前以抗幽门螺杆菌（Hp）、补充维生素、叶酸、非甾体类药物为主，同时密切随访，其疗效尚有争议。中医药治疗PLGC独具特色，且已有许多研究证实其疗效可靠，但具体机制尚未完全明确，故综述PLGC的常见信号通路及中医药治疗机制的研究进展。 |
| 关键词: 胃癌前病变 信号通路 中医药 |
| DOI：10.11656/j.issn.1672-1519.2020.02.24 |
| 分类号:R735.2 |
| 基金项目:国家重点研发计划（2017YFC1700601）。 |
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| Signal pathways of precancerous lesions of gastric cancer and the related research progress of traditional Chinese medicine treatment |
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ZHANG Manling1, SHI Zhaohong2, LIU Yun1, ZHAO Wenyingzi1
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1.Hubei University of Chinese Medicine, Wuhan 430065, China;2.Wuhan Hospital of Traditional Chinese Medicine and Western Medicine, Affiliated to Hubei University of Chinese Medicine, Wuhan 430022, China
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| Abstract: |
| The incidence and mortality of gastric cancer among all kinds of cancers are both high in China. The precancerous lesion of gastric cancer (PLGC) plays an important role in the process of gastric carcinogenesis. Earlier diagnosis and treatment of PLGC can reduce the risk of developing into gastric cancer. At present,the therapy methods of PLGC contains anti-Hp treatment,supplement of kinds of vitamins,folic acid,non-steroidal drugs,and intensive follow-up. However,the curative effects of above strategies are still controversial. The traditional Chinese medicine (TCM) has its unique feature. It has been proved by many researches that the TCM has significant effect in PLGC treatment,but the mechanism is not completely clear. This article summarizes the dominating signal pathways of precancerous lesions of gastric cancer and the related research progress of TCM. |
| Key words: precancerous lesion of gastric cancer signal pathway traditional Chinese medicine |
