| 摘要: |
| [目的] 通过现代检验技术研究筋疽（糖尿病足非缺血性坏疽）湿热毒盛证的糖脂代谢指标。[方法] 收集136例筋疽（糖尿病足非缺血性坏疽）患者进行不同证型间指标的比较。[结果] 湿热毒盛证患者空腹血糖（FBG）、糖化血红蛋白（HbA1c）、餐后2 h血糖（2 hPBG）、晚期糖基化终末产物（AGEs）、白蛋白（ALB）、总胆固醇（TC）、高密度脂蛋白（HDL-C）与其他证型比较存在统计学差异（P<0.05）。湿热毒盛证患者C-反应蛋白（CRP）、人可溶性血管细胞黏附分子1（sVCAM-1）与其他证型组间比较存在统计学差异（P<0.01）。[结论] 筋疽（糖尿病足非缺血性坏疽）湿热毒盛证形成的原因与低营养状态下糖脂代谢紊乱引起的高血糖及持续炎症反应相关。 |
| 关键词: 筋疽（糖尿病足非缺血性坏疽） 湿热毒盛证 糖脂代谢 |
| DOI：10.11656/j.issn.1672-1519.2020.03.14 |
| 分类号:R587.1 |
| 基金项目:国家中医药传承与创新“百千万人才工程”（岐黄工程）-第六批全国老中医药专家学术继承项目（2017-29）；上海市科委中医引导类项目（18401903600）；上海市进一步加快中医药事业发展三年行动计划项目[ZY（2018-2020）-CCCX-4005]；上海市卫计委科研面上项目（201740093）；上海市虹口区“国医强优”三年行动计划项目（HGY-MGB-2018-01-02）。 |
|
| Study on dampness-heat syndrome of jin ju (non-ischemic gangrene of diabetic foot) based on glucose and lipid metabolism |
|
LI Liangliang1, WANG Weiling1, ZHAO Cheng1,2
|
|
1.Department of Vascular Anomalies, Shanghai University of Traditional Chinese Medicine, Shanghai TCM-Integrated Hospital, Shanghai 200082, China;2.Clinical Laboratory, Shanghai TCM-Integrated Institute of Vascular Anomalies, Shanghai 200082, China
|
| Abstract: |
| [Objective] Study on glucose and lipid metabolism indexes of dampness-heat syndrome of jin ju (non-ischemic gangrene) in diabetic foot by modern testing techniques.[Methods] A total of 136 patients with jin ju (diabetic foot non-ischemic gangrene) were collected and compared for different syndrome types.[Results] The levels of FBG,HbA1c,2 hPBG,AGEs,ALB,TC,HDL-C in patients with dampness-heat syndrome were different from those in other syndromes of jin ju (non-ischemic gangrene) (P<0.05). And the levels of CRP and sVCAM-1 in patients with dampness-heat syndrome were significantly different from those in other syndromes of jin ju (non-ischemic gangrene) (P<0.01).[Conclusion] The cause of the formation of jin ju (non-ischemic gangrene) dampness-heat toxin in diabetic foot is related to hyperglycemia and persistent inflammatory response caused by disorders of glucose and lipid metabolism in low-nutrition conditions. |
| Key words: jin ju (non-ischemic gangrene of diabetic foot) dampness heat and excessive toxin syndrome glucose and lipid metabolism |
