中药及中药复方治疗肥胖的作用靶点探析

Analysis on the target of traditional Chinese medicine and traditional Chinese medicine compound in treating obesity

关键词:  肥胖  中药  中药复方  靶点

Key words:  obesity  traditional Chinese medicine  traditional Chinese medicine compound  target

摘要:

肥胖是由于摄入能量大于消耗能量导致脂肪异常堆积的一种代谢性疾病，与遗传、免疫、情绪、环境、内分泌等多种因素有关。肥胖增加了心血管疾病、肿瘤、糖尿病、骨关节炎和慢性肾病的风险，已经成为中等收入国家公共卫生面临的主要挑战。目前市场上的减肥药有两大类，胰脂肪酶抑制剂和作用于中枢神经系统的食欲抑制剂，治疗措施虽有效，但是存在许多不良反应，不能确定其安全性。中药及中药复方治疗肥胖的疗效在临床研究及动物实验中得到广泛验证，以中药及中药复方治疗肥胖为线索，阐述中药及中药复方治疗肥胖的理论基础，从脂肪组织形成和代谢的关键因子角度，总结中药及中药复方治疗肥胖的作用靶点，提出过氧化物酶体增殖物激活受体-γ（PPAR-γ）、腺苷酸活化蛋白激酶（AMPK）、瘦素（Leptin）、解偶联蛋白1（UCP1）为其共性作用靶点，旨在为今后中药及中药复方治疗肥胖的实验设计和新药研发提供依据。

Abstract:

Obesity is a metabolic disease in which the intake of energy is greater than the energy consumed,resulting in abnormal accumulation of fat,which is related to genetic,immune,emotional,environmental,endocrine and other factors. Obesity increases the risk of cardiovascular disease,cancer,diabetes,osteoarthritis and chronic kidney disease and has become a major public health challenge for middle-income countries. There are two major types of diet pills on the market,pancreatic lipase inhibitors and appetite suppressants acting on the central nervous system. Although the treatment measures are effective,there are many adverse reactions and their safety cannot be determined. The efficacy of traditional Chinese medicine and traditional Chinese medicine compound in the treatment of obesity has been widely verified in clinical research and animal experiments. The traditional Chinese medicine and traditional Chinese medicine compound treatment of obesity as a clue to explain the theoretical basis of traditional Chinese medicine and traditional Chinese medicine compound for treating obesity,from the perspective of key factors in the formation and metabolism of adipose tissue,in order to summarize the therapeutic targets of traditional Chinese medicine and traditional Chinese medicine in the treatment of obesity,and propose PPAR-γ,AMPK,Leptin and UPC1 as their common targets,aiming to provide a basis for the experimental design and new drug development of traditional Chinese medicine and traditional Chinese medicine compound for the treatment of obesity.