网络药理学在中医药治疗慢性肾脏病中的研究现状

Research progress of network pharmacology in the treatment of chronic kidney disease with traditional Chinese medicine

关键词:  网络药理学  中医药  慢性肾脏病

Key words:  network pharmacology  traditional Chinese medicine  chronic kidney disease

摘要:

慢性肾脏病（CKD）是病程长、发病机制复杂的一类疾病，中医药在其治疗中发挥了重要作用。目前，网络药理学已成为中药治疗CKD的有效研究方法。网络药理学在系统生物学的基础上，运用高通筛选及网络分析等技术，建立“药物－基因－靶点－疾病”网络，系统阐述机体与药物间作用的原理与规律，与中药多途径、多靶点特点相契合。通过网络药理学在中医药治疗CKD研究发现，中医药在改善CKD的氧化应激状态、调节炎症反应、减缓肾脏纤维化和细胞凋亡方面起到不可或缺的作用。文章对网络药理学在CKD领域相关研究进行归纳和总结，以期为网络药理学对中医药治疗CKD的进一步研究提供参考。

Abstract:

Chronic kidney disease (CKD) is a kind of disease with long course and complicated pathogenesis. Traditional Chinese medicine (TCM) plays an important role in the treatment of chronic kidney disease. At present,network pharmacology has become an effective research method for the treatment of chronic kidney disease with traditional Chinese medicine. On the basis of systems biology,network pharmacology established the "drug-gene-target-disease" network by using the techniques of omics,high-pass screening and network analysis,systematically expounded the principle and law of the interaction between the body and the drug,which was consistent with the characteristics of multi-pathways and multi-targets of TCM. Through the research of network pharmacology in the treatment of chronic kidney disease with TCM,it has been found that TCM plays an indispensable role in improving the oxidative stress state of CKD,regulating the inflammatory response,and slowing down the renal fibrosis and cell apoptosis. This paper summarizes the research on network pharmacology in the field of CKD,so as to provide reference for further research on the mechanism of TCM in the treatment of chronic kidney disease.