静宁方治疗儿童注意缺陷多动障碍的疗效评价及对胃肠功能的影响

Effect of Jingning Prescription on attention deficit hyperactivity disorder and in children itsinfluence on gastrointestinal function

关键词:  注意缺陷多动障碍  静宁方  胃肠功能  胃动素  胃泌素

Key words:  attention deficit hyperactivity disorder  Jingning Prescription  gastrointestinal function  MTL  GAS

摘要:

[目的] 探究静宁方治疗儿童注意缺陷多动障碍（ADHD）的疗效及对胃肠功能，即胃肠道症状和血清胃动素、胃泌素水平的影响。[方法] 收集30例ADHD患儿作为ADHD组；同时期纳入25例相同年龄段健康儿童作为空白对照组。比较两组儿童的一般资料，采用SNAP-Ⅳ和Conners儿童行为量表（父母）对ADHD组患儿分别于治疗前后进行注意力、多动冲动行为以及品行问题、学习问题、身心障碍、冲动多动、焦虑和多动指数评分；采用胃肠疾病中医症状评分表对ADHD组治疗前后以及空白对照组进行胃肠道症状评分；采用酶联免疫吸附法（ELISA）分别检测ADHD组治疗前后以及空白对照组胃动素、胃泌素水平。[结果] 两组儿童性别、年龄等一般资料差异无统计学意义（P>0.05）。ADHD组经静宁方治疗后SNAP-Ⅳ、Conner儿童行为量表（父母）各项积分改善明显，差异有统计学意义（P<0.05）。ADHD组治疗前胃肠疾病中医症状评分表积分明显高于空白对照组，差异有统计学意义（P<0.05）；经治疗后，积分下降明显，差异有统计学意义（P<0.05）。ADHD组治疗前血清胃动素水平低于空白对照组；经静宁方治疗后血清胃动素水平显著提高，两组数据差异有统计学意义（P<0.05）。ADHD组治疗前血清胃泌素水平高于空白对照组；经治疗后血清胃泌素水平降低显著，两组数据比较差异有统计学意义（P<0.05）。[结论] 静宁方可以明显改善ADHD患儿SNAP-Ⅳ量表、Conners儿童行为量表（父母）积分和胃肠道症状，对ADHD患儿血清胃动素、胃泌素水平有明显的调节作用，疗效确切。

Abstract:

[Objective] To explore the therapeutic effect of Jingning Prescription on attention deficit hyperactivity disorder(ADHD) in children and its influence on serum MTL and GAS levels. [Methods] The 30 children with ADHD were collected as ADHD group. In the same period, 25 healthy children of the same age were included as the blank control group. The general data of the two groups of children were compared. Nolan and Pehlam version IV (SNAP-Ⅳ) Scale and Conners Child Behavior Scale (Parents) were used to score children with ADHD before and after treatment for their attention, hyperactivity and impulsiveness, conduct problems, learning problems, psychosomatic disorders, impulsive hyperactivity, anxiety, and hyperactivity index. Traditional Chinese Medicine (TCM) Symptom Scale for gastrointestinal diseases was used to score children of blank control group and ADHD group, before and after treatment, for their gastrointestinal symptoms.Detect the motilin(MTL) and gastrin(GAS) levels in serum both of blank control group and ADHD group before and after treatment. [Results] There was no significant difference in gender and age between the two groups (P>0.05). The score of TCM symptom Scale of Gastrointestinal Diseases before treatment in ADHD group was significantly higher than that in blank control group, and the difference was statistically significant (P<0.05). After treatment, the score decreased significantly and the difference was statistically significant (P<0.05). The SNAP-Ⅳ Scale and Conner Child Behavior Scale (Parents) scores of ADHD group after treatment with Jingning prescription were significantly decreased, and the difference was statistically significant(P<0.05). The serum MTL level of ADHD group was lower than that of blank control group before treatment.After treatment with Jingning Prescription, serum MTL level was significantly increased, and the difference between the two groups was statistically significant (P<0.05). Before treatment, the serum GAS level of ADHD group was higher than that of blank control group.After treatment, the serum GAS level decreased significantly, and the difference between the two groups was statistically significant (P<0.05). [Conclusion] Jingning Prescription can significantly decrease Conner Child Behavior Scale (Parents) scores of ADHD children, and has an obvious regulating effect on serum MTL and GAS levels of ADHD children, with an exact therapeutic effect.