基于脑肠轴理论胆囊收缩素在消化系统和中枢神经系统的作用研究进展

Research progress on the role of cholecystokinin in digestive system and central nervous system based on brain-gut axis theory

关键词:  胆囊收缩素  脑肠轴  消化系统  中枢神经系统

Key words:  cholecystokinin  brain-gut axis  digestive system  central nervous system

摘要:

脑肠轴是沟通人体消化系统和神经系统的桥梁，脑肠肽则是构架这一桥梁的重要作用因子。胆囊收缩素作为一种典型的脑肠肽，广泛存在于人体消化系统、中枢神经系统、外周血液等组织器官中，参与胃肠运动、食欲调节、激素分泌、神经保护等诸多过程，与学习、记忆、情感等高级行为密切相关，并通过脑肠轴形成上下双向调节环路，将人体中枢及胃肠系统密切联系起来，从而在多种生理及病理过程中发挥作用。现基于脑肠轴理论总结其在消化系统和中枢神经系统的作用研究进展。

Abstract:

The brain-gut axis is the bridge that communicates the human digestive system and the nervous system. Brain-gut peptide is an important factor in the construction of this bridge. As a typical brain-gut peptide, cholecystokinin is widely distributed in human digestive system, central nervous system, peripheral blood and other tissues and organs, and participates in many processes such as gastrointestinal exercise, appetite regulation, hormone secretion, and neuroprotection. It is closely related to advanced behaviors such as learning, memory, and emotion. It forms a two-way circular regulation loop through the brain-intestinal axis, which closely links the human central and gastrointestinal systems, and thus plays a role in various physiological and pathological processes. Based on the theory of brain-gut axis, the research progress in the digestive system and central nervous system is summarized.