药食同源类中药防治帕金森病的研究进展

Research progress on herbs of medicine food homology for treating Parkinson's disease

关键词:  帕金森病  药食同源类中药  药食同源  动物模型  氧化应激

Key words:  Parkinson's disease  herbs of medicine food homology  medicine food homology  animal model  oxidative stress

摘要:

帕金森病（PD）是一种常见的神经退行性运动障碍，在老年群体中高发。近年来，PD患者的数量在世界范围内迅速增加，但是病理机制仍然不明确，目前临床上常用的PD治疗药物左旋多巴胺，具有一定的不良反应。而药食同源类中药因为其低毒特性以及对PD的神经保护潜力而受到越来越多的关注。大量研究表明，某些药食同源类中药可以通过改善线粒体功能，减轻氧化应激和减少神经细胞凋亡发挥抗PD的作用。药食同源类中药可能是具有前景的抗PD药物，因此文章对PD常见的的实验模型、药食同源类中药的活性成分及其可能的治疗机制进行综述。

Abstract:

Parkinson's disease (PD) is the most common neuro-degenerative disease which occurs highly in the aged. The number of PD patients is increasing rapidly worldwide, however, the mechanism of the disease remains unclear. At present, levodopamine, commonly used to PD treatment in clinical practice, has certain side effects. Due to their low toxicity characteristic and neuroprotective potential in PD, herbs of medicine food homology (MFH) are attracting more and more attention. Extensive researches have shown that some herbs of MFH exert anti-Parkinsonian potential by improving mitochondrial function, alleviating oxidative stress and reducing neuronal apoptosis. Therefore, herbs of MFH may be promising anti-Parkinsonian drugs. The review highlights the common experimental models of PD and the neuroprotective potential of some herbs of MFH.