浅析外泌体参与针刺调节作用的特点分析

A brief analysis of the characteristics of exosome participating in the regulation of acupuncture

关键词:  外泌体特点  针灸作用特点  针灸机制  针灸转化

Key words:  exosome characteristics  the characteristics of acupuncture and moxibustion  mechanism of acupuncture  transformation of acupuncture

摘要:

针灸作为一种物理刺激，在穴位局部被感知并转化传递到病变部位发挥效应的过程是复杂的。直至目前针灸的起效机制尚未完全阐明。外泌体作为细胞间通讯的新方式，前期研究发现针灸可以调控外泌体的释放，外泌体与针效之间关系密切，发现外泌体可能在针刺信息传递过程中发挥重要作用，是针刺信息传递的重要途径。外泌体具有分布广、来源广、运载物质多、产生效应多、靶向运输、组织来源特异性、临床应用安全稳定等特点，可能与针灸整体网络调节、“气至病所”、脏腑-经穴相关、针灸血清药转化应用等存在密切联系，文章对外泌体与针灸作用特点进行梳理、分析，为阐释针灸作用原理，促进针灸基础研究临床转化提供新思路。

Abstract:

As a kind of physical stimulation,acupuncture is sensed locally at the acupoint and transferred to the lesion site to exert its effect is complex. Up to now,the effective mechanism of acupuncture has not been fully clarified. As a new way of intercellular communication,our previous studies found that acupuncture can regulate the release of exocrine,and there is a close relationship between exocrine and acupuncture effect. It is found that exocrine may play an important role in the process of acupuncture information transmission. It is an important way of acupuncture information transmission. The exosome body has the characteristics of wide distribution,wide source,many carrying substances,many effects,targeted transportation,tissue source specificity,clinical application safety and stability,and so on. It may be closely related to the whole network regulation of acupuncture and moxibustion,"qi to disease place",viscera-meridian acupoint correlation,acupuncture serum drug conversion application and so on. This paper combs and analyzes the characteristics of exocrine and acupuncture in order to explain the principle of acupuncture and moxibustion. To provide new ideas for promoting clinical transformation of basic research on acupuncture and moxibustion.