天津地区中西医结合治疗新型冠状病毒肺炎的用药及疗效分析

Analysis on the medication and efficacy of integrated traditional Chinese and Western medicine in the treatment of COVID-19 in Tianjin area

关键词:  天津地区  新型冠状病毒肺炎  中西医结合  疗效  关联规则

Key words:  Tianjin area  COVID-19  integrated traditional Chinese and Western medicine  curative effect  association rule

摘要:

[目的] 对天津地区中西医结合治疗新型冠状病毒肺炎（简称新冠肺炎，下同）的用药及疗效情况进行总结。[方法] 对天津地区132例经中西医结合系统治疗后达到出院标准的新冠肺炎本土确诊病例进行用药情况总结及临床疗效评价。[结果] 在132例患者中，整体男性多于女性，发病以中年群体为主，分型以普通型和重型为主。入院时腹泻、纳呆、恶心等脾胃症状较常见，同时发热、咳嗽、咯痰、少汗等湿邪困表袭肺的表现亦不少见，小便黄、口干、口苦等热象，乏力、气短等本虚表现以及暗红舌等瘀象也有体现。中药治疗方面，最常用半夏、茯苓、陈皮、厚朴、白术、虎杖、神曲、薏苡仁、豆蔻、广藿香、黄连、紫菀，西药治疗最常用抗病毒药物，比如利托那韦和阿比多尔，两者合用比例也高（59.1%），其他药物如重组人干扰素α-2b及乙酰半胱氨酸片，应用人数亦超过50%，喹诺酮类抗生素也相对多用。经过系统的中西医结合治疗，患者壮热、恶寒、头痛、身重等症状消失率达100%，纳呆、恶心、低热、咯痰、少汗、口苦、小便黄、少气懒言、喘促等症消失率也达到了80%以上，临床症状明显改善，生活质量明显提高，多项实验室指标均显示出了向好趋势。[结论] 中西医结合治疗新冠肺炎患者，可明显改善临床症状及生活质量，促进了核酸转阴，痊愈出院。

Abstract:

[Objective] To summarize the medication and efficacy of integrated traditional Chinese and Western medicine in the treatment of COVID-19 in Tianjin. [Methods] The medication uses and clinical efficacy evaluation of 132 local confirmed cases of COVID-19 who met discharge standards after treatment with integrated traditional Chinese and Western medicine in Tianjin were summarized. [Results] Among the 132 patients,there were more males than females. The diseased population was mainly the middle-aged,and the types were normal and severe types mainly. Spleen and stomach symptoms such as diarrhea,anorexia,nausea was common. At the same time,the symptoms of dampness invading the lung such as having fever,cough,expectoration,and hypohidrosis were also common. There were also heat syndromes such as yellow urine,dry mouth,bitter mouth,original deficiency syndromes such as fatigue and shortness of breath,and blood stasis syndromes such as dark red tongue. In traditional Chinese medicine treatment,the most commonly used drugs were Pinellia ternata,Poria cocos,dried Tangerine Peel,Magnolia officinalis,Atractylodis Macrocephalae Rhizoma,Knotweed,Medicated Leaven,Semen Coicis,Amomi Fructus Rotundus,Herba Agastaches,Coptis chinensis and Aster tataricus. In Western medicine treatment,the most commonly used drugs were antiviral drugs such as ritonavir and arbidol,and the combination of the two drugs were also high (59.1%). The number of patients who use other drugs such as recombinant human interferon α-2b and acetylcysteine tablets are more than 50%. Quinolone antibiotics were also used. After the systematic combination of traditional Chinese and western medicine treatment,the patient's symptoms such as strong heat,aversion to cold,headache,heavy body disappeared up to 100%. The disappearance rate of symptoms such as anorexia,nausea,low-grade fever,expectoration,hypohidrosis,bitter mouth,yellow urine,less breath,lazy talk,and shortness of breath also reached more than 80%. The clinical symptoms and the quality of life improved significantly. Many laboratory indicators showed positive trend. [Conclusion] Integrated traditional Chinese and western medicine treatment of COVID-19 patients can significantly improve the patients' clinical symptoms and quality of life,and promote the negative result of nucleic acid,recovery and discharge from hospital.