| 摘要: |
| 失眠是临床常见病，难治病。微生物-肠-脑轴已被证实与神经、消化、内分泌、呼吸等多系统疾病相关。近年来，有研究表明，肠道菌群与失眠关系密切，而中药能通过调节肠道菌群失稳改善睡眠。文章从微生物-肠-脑轴理论、相关中医理论基础及基于微生物-肠-脑轴理论对中医调节肠道菌群治疗失眠的研究进展等方面进行论述，以期为中医药治疗失眠的机制研究提供新的思路。 |
| 关键词: 微生物-肠-脑轴 肠-脑轴 肠道菌群 失眠 中医 |
| DOI：10.11656/j.issn.1672-1519.2022.04.25 |
| 分类号:R256.23 |
| 基金项目:深圳市医疗卫生三名工程项目（SZSM201512043）；李惠林广东省名老中医药专家传承工作室建设项目。 |
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| Research progress in the treaditional Chinese madicine treatment of insomnia by adjusting intestinal flora based on microbiota-gut-brain axis theory |
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HUANG Qian1, ZENG Lin1, WANG Gaoxiang2, LI Huilin1,3
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1.The Fourth Clinical Medicine College of Guangzhou University of Chinese Medicine, Shenzhen 518033, China;2.Nanjing University of Chinese Medicine, Nanjing 210000, China;3.Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China
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| Abstract: |
| Insomnia is a clinical disease which is prevalent but difficult to cure. The microbiota-gut-brain axis has been shown to be associated with many systemic diseases,such as neurological,digestive,endocrine,respiratory diseases. In recent years,some studies have shown that gut microbiota is closely related to insomnia,and continuous clinical and experimental studies have shown that traditional Chinese medicine(TCM) can improve insomnia by regulating intestinal flora instability. This paper discusses the overview of the microbiota-gut-brain axis,the theoretical basis of TCM and the research progress of regulating intestinal flora in TCM based on the theory of microbiota-gut-brain axis and so on,in order to provide new ideas for the treatment of insomnia. |
| Key words: microbiota-gut-brain axis gut-brain axis gut microbiota insomnia traditional Chinese medicine |
