中西医结合治疗天津地区奥密克戎新型冠状病毒感染患者核酸转阴时间的影响因素分析

Factor analysis of nucleic acid turning negative time of novel coronavirus Omicron infection patients treated by integrated traditional Chinese and Western medicine in Tianjin area

关键词:  天津地区  新型冠状病毒  奥密克戎变种  中西医结合  核酸转阴时间

Key words:  Tianjin area  novel coronavirus  Omicron variant  integrated traditional Chinese and Western medicine  nucleic acid turning negative time

摘要:

[目的] 探讨天津地区中西医结合治疗新型冠状病毒奥密克戎变种感染患者核酸转阴时间的影响因素。[方法] 筛选新型冠状病毒奥密克戎变种感染患者的电子病历，提取住院号、性别、年龄、疫苗接种信息、既往慢性病情况、临床分型、合并前期症状、发病日期、入院日期、中医首次会诊日期、中医首诊辨证用药信息、核酸转阴日期等资料，采用回顾性分析方法，以患者核酸检测转阴时间作为结局观察指标，并以其平均值分组，比较组间临床特征指标差异，采用多元性线性回归分析评价结局的影响因素。[结果] 筛选病历398例，剔除219例，纳入研究179例，分组后组间在合并慢性疾病、合并前期症状、入院时间差、中西医结合干预时间、中医证型分类等5项指标比较上差异具有统计学意义（P<0.05）；多元线性回归分析显示合并慢性疾病、中西医结合干预时间、中医证型分类等3项与患者核酸转阴时间呈正相关（P<0.05）。[结论] 合并慢性疾病、较晚中西医结合干预及中医辨证分类为兼杂证会延长新型冠状病毒奥密克戎变种感染患者核酸转阴时间。

Abstract:

[Objective] To investigate the influencing factors of nucleic acid negative conversion time in patients infected with novel coronavirus Omicron variant treated with integrated Chinese and Western medicine in Tianjin area.[Methods] Screen electronic medical records of novel coronavirus Omicron variant infection patients,extract hospitalization number,gender,age,vaccination information,previous chronic diseases,clinical typing,combined early symptoms,onset date,admission date,date of first consultation of traditional Chinese medicine(TCM),dialectical drug use information of TCM at first diagnosis,nucleic acid negative conversion date,retrospective analysis method was adopted,the time of patients' nucleic acid test turning negative was used as the outcome observation index,and the patients were divided into groups with the mean value. The differences of clinical characteristic indexes between groups were compared. Multivariate linear regression analysis was used to evaluate the influencing factors of outcome.[Results] The 398 cases of medical records were screened,219 cases were excluded,and 179 cases were included in the study. After grouping,there were statistically significant differences between groups in the comparison of indicators such as complicated chronic diseases,complicated early symptoms,time difference between admission,intervention time of integrated traditional Chinese and Western medicine,and classification of TCM syndromes (P<0.05). Multiple linear regression analysis showed that there was a positive correlation between the time of nucleic acid conversion and chronic diseases,the intervention time of integrated traditional Chinese and Western medicine,and the classification of TCM syndromes (P<0.05).[Conclusion] Combined with chronic diseases,late intervention of integrated Chinese and Western medicine and dialectical classification of Chinese medicine as mixed syndromes can prolong the negative nucleic acid conversion time of patients infected with novel coronavirus Omicron variant.