基于LIBS的中药质量检测技术与应用

Quality testing technology and application of traditional Chinese medicine based on LIBS

关键词:  激光诱导击穿光谱  中药制造过程  质量控制

Key words:  laser-induced breakdown spectroscopy  traditional Chinese medicine manufacturing process  quality control

摘要:

基于中药制药生产质量管理需求，探讨了激光诱导击穿光谱（LIBS）技术在中药制药领域中的应用，分析了LIBS技术工作原理和检测技术优势，该技术具有方便，快捷，以及精度较高的检测特点。从LIBS技术特点出发，分别举例分析了该技术在中药原料质量检测、制造过程质量控制、中药产品质量控制，以及LIBS技术与其他光谱联用技术研究方面的应用情况，显示了LIBS技术与中药过程质量控制的结合潜力。中药自身复杂成分的特点限制了LIBS技术的应用。文章提出LIBS技术可以从两个方面深入研究提高技术优势，一是深入挖掘LIBS技术与化学计量学方法结合，提升检测精度，二是强化与其他光谱联用技术，降低检测误差，为该技术在中药智能制造过程质量控制的实际应用提出参考。

Abstract:

Based on the quality management needs of Chinese medicine pharmaceutical production, this paper discusses the application of laser-induced breakdown spectroscopy(LIBS) in the pharmaceutical technical field of traditional Chinese medicine (TCM), and analyze the technical work of LIBS technology and technical advantages. LIBS has the advantages of convenience, fast and high accuracy to fully meet the demand of quality management of TCM pharmaceutical production. On the base of its characteristics, LIBS has been employed into four areas of technologyincluding quality inspection of raw materials, the quality control of manufacturing process, production quality control and the technology of combining with other spectra. These applications demonstrate the potential of combining LIBS technology with TCM. Characteristics of TCM self-complex ingredients limits LIBS technology. This manuscript summarizes two technical breakthroughs of its specific application. One is to combine LIBS with stoichiometric methods to achieve accurate spectral resolution of fingerprints of inorganic ions. The other is to enhance the technique of combining with other spectra to improve detection accuracy. From what has been discussed above, theactual application of this technology of quality controlin the field of TCM intelligent manufacturing processcould provide reference.