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| 内皮细胞在冠状动脉无复流中的作用和中药保护研究进展 |
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李培杰1, 郑先先1, ODURO Patrick Kwabena1, 冷玲1,2, 李玉红1,2, 黎瑞巧1,2, 王启隆1,2
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1.天津中医药大学中医药研究院, 天津 301617;2.组分中药国家重点实验室, 天津 301617
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| 摘要: |
| 经皮冠状动脉介入治疗是治疗急性ST段抬高型心肌梗死的最佳再灌注策略，但冠状动脉血管解除狭窄后，部分心脏梗死区的微循环未获得充分的血流灌注，即为无复流现象，可导致急性ST段抬高型心肌梗死患者心力衰竭并增加病死率。内皮细胞在无复流中扮演了重要角色，是近些年来的研究热点。本文对无复流现象中涉及到的内皮细胞损伤进行探讨，并总结了中药改善内皮细胞损伤和无复流现象的研究进展。 |
| 关键词: 内皮细胞 心肌缺血再灌注 无复流 中药 |
| DOI：10.11656/j.issn.1672-1519.2022.09.24 |
| 分类号:R259 |
| 基金项目:国家自然科学基金项目(81973624);天津市自然科学基金面上项目(19JCYBJC28200);天津市科技计划项目(20ZYJDJC00070,21ZYJDJC00070)。 |
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| The role of endothelial cell in coronary myocardial no-reflow phenomenon and advances on the protective effect of traditional Chinese medicine |
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LI Peijie1, ZHENG Xianxian1, ODURO Patrick Kwabena1, LENG Ling1,2, LI Yuhong1,2, LI Ruiqiao1,2, WANG Qilong1,2
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1.Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2.Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Tianjin 301617, China
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| Abstract: |
| Percutaneous coronary intervention is the best reperfusion strategy for acute ST-segment elevation myocardial infarction.However,after coronary artery stenosis has been released,microcirculation to the part of the infarcted tissue is impaired.This phenomenon is termed "no-reflow",and it is a strong predictor of heart failure and increased mortality among ST segment elevation myocardial infarction patients.Endothelial cells play an important role in no-reflow and are a research hotspot in recent years.In view of this,injury to cardiac microvascular endothelial cells contributes significantly to myocardial "no-reflow" phenomenon.This article discusses the endothelial cell damage involved in no-reflow and the research progress of traditional Chinese medicine in improving endothelial cell injury and no-reflow was summarized. |
| Key words: endothelial cell myocardial ischemia-reperfusion no-reflow traditional Chinese medicine |
