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| 基于顶空气相色谱质谱联用技术的紫雪散挥发性成分研究 |
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宋玲玲1,2,3, 穆琦瑄1,2,3, 王帆4, 张慧4, 柴欣1,2,3, 王跃飞1,2,3, 崔英1,2,3
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1.天津中医药大学中医药研究院, 天津 301617;2.天津中医药大学组分中药国家重点实验室, 天津 301617;3.天津市中药化学与分析重点实验室, 天津 301617;4.天津宏仁堂药业有限公司, 天津 300385
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| 摘要: |
| [目的] 建立顶空气相色谱质谱联用技术（HSGC-MS）快速鉴定紫雪散中挥发性成分的方法，分析不同批次、不同工艺的紫雪散样品中挥发性成分的差异。[方法] 采用HSGC-MS技术建立紫雪散中挥发性成分的分析方法，利用NIST17标准谱库鉴定紫雪散挥发性成分，并归属各成分的药材来源，运用峰面积归一化法测定各成分的相对含量。[结果] 从紫雪散中共鉴定了46个挥发性成分，包括醇类、酯类、醛类、酮类、酸类、烃类及含氮化合物等，其中最主要成分为麝香酮。不同批次、不同工艺的紫雪散样品中各成分相对含量存在较大差异。[结论] 系统阐释了紫雪散中挥发性成分，为科学评价及有效控制紫雪散质量提供了依据。 |
| 关键词: 紫雪散 挥发性成分 顶空进样 气质联用 |
| DOI：10.11656/j.issn.1672-1519.2022.11.19 |
| 分类号:R284.1 |
| 基金项目:天津市科技计划项目（20ZYJDJC00070）。 |
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| Study on volatile components in Zixue Powder by headspace gas chromatography mass spectrometry |
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SONG Lingling1,2,3, MU Qixuan1,2,3, WANG Fan4, ZHANG Hui4, CHAI Xin1,2,3, WANG Yuefei1,2,3, CUI Ying1,2,3
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1.Institute of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2.State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Medicine, Tianjin 301617, China;3.Tianjin Key Laboratory of Traditional Chinese Medicine Chemistry and Analysis, Tianjin 301617, China;4.Tianjin Hongrentang Pharmaceutical Co., Ltd., Tianjin 300385, China
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| Abstract: |
| [Objective] To establish a rapid analytical method for identifying the volatile components in Zixue Powder by headspace gas chromatography mass spectrometry(HS GC-MS) and evaluate the difference of the volatile components among different batches and different processes of Zixue Powder sample.[Methods] The analytical method of volatile components in Zixue Powder was established by HS GC-MS. The compounds were identified by NIST 17 database retrieval and traced to the herbal sources. The relative content of each compound was determined by peak area normalization method.[Results] The 46 volatile compounds were characterized from Zixue Powder,including alcohols,esters,aldehydes,ketones,acids,hydrocarbons and nitrogenous compounds,and the main compound was muscone. There were great differences in the relative content of the volatile components among different batches and processes of Zixue Powder sample.[Conclusion] The volatile components in Zixue Powder were characterized,which provides a basis for scientific evaluation and effective quality control of Zixue Powder. |
| Key words: Zixue Powder volatile component headspace injection gas chromatography mass spectrometry |
