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| 白芍总苷治疗干燥综合征的研究进展 |
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郭小静1,2,3, 刘维1,2,3, 卡玉秀1,2,3, 丁久力1,2,3, 岳青云1,2,3, 林芳芳1,2,3, 陈婌娟1,2,3, 顾庆香1,2,3
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1.天津中医药大学第一附属医院, 天津 300381;2.国家中医针灸临床医学研究中心, 天津, 300381;3.天津中医药大学, 天津 301617
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| 摘要: |
| 干燥综合征（SS）是一种慢性自身免疫性疾病，常侵犯泪腺、唾液腺等外分泌腺，同时还会造成肺、肾、消化和神经系统损害甚至累及全身器官。其病因复杂，发病机制目前尚未完全阐明。本病临床治疗为对症治疗，常用药物为免疫抑制剂，糖皮质激素等。白芍总苷辅助治疗本病可改善患者的外分泌腺功能，具有较好的临床疗效和安全性。本文从白芍总苷治疗SS的相关机制进行综述，以期为相关实验研究及临床提供更多的理论依据。 |
| 关键词: 干燥综合征 白芍总苷 研究进展 综述 |
| DOI：10.11656/j.issn.1672-1519.2022.12.21 |
| 分类号:R442.8 |
| 基金项目:国家重点研发计划项目(2018YFC1705201);国家自然科学基金面上项目(82074377);国家中医药管理局中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者。 |
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| Progress in total glucosides of paeony on sjogren’s syndrome |
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Guo Xiaojing1,2,3, LIU Wei1,2,3, KA Yuxiu1,2,3, DING Jiuli1,2,3, YUE Qingyun1,2,3, LIN Fangfang1,2,3, CHEN Shujuan1,2,3, GU Qingxiang1,2,3
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1.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China;2.National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China;3.Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
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| Abstract: |
| Sjogren's syndrome(SS) is a chronic autoimmune disease that often infringes on the lacrimal glands and salivary glands and other exocrine glands,but also causes lung,kidney,digestive and nervous system damage and even involves systemic organs. Its etiology is complex,and the pathogenesis has not been fully elucidated. The clinical treatment of this disease is symptomatic treatment,and the commonly used drugs are immunosuppressants,glucocorticoids,etc. Total glucosides of paeony adjuvant therapy in this disease can improve patient exocrine gland function and have good clinical efficacy and safety. In this paper,the relevant mechanisms of total glucosides of paeony treatment in SS are reviewed to provide more theoretical basis for relevant experimental research and clinical practice. |
| Key words: sjogren's syndrome total glucosides of paeony research progress review |
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