尿毒清颗粒辅助治疗血液透析高磷血症的临床疗效分析

Clinical effect of Niaoduqing Granule combined with calcium carbonate and blood perfusion in the treatment of hyperphosphatemia after hemodialysis

关键词:  慢性肾脏病  血液透析  高磷酸血症  血液灌流  尿毒清颗粒

Key words:  chronic kidney disease  hemodialysis  hyperphosphatemia  blood perfusion  Niaoduqing Gramule

摘要:

[目的] 探究尿毒清颗粒联合碳酸钙、血液灌流治疗血液透析高磷血症的临床疗效及对患者生活质量的影响。[方法] 将101例患者随机分为观察组51例，对照组50例，两组均予以碳酸钙、血液灌流等基础治疗，观察组在基础治疗同时加用尿毒清颗粒，对照组予以同规格安慰剂，两组均治疗3个月，比较两组临床疗效、炎性反应、全段甲状旁腺素、贫血三项指标、血磷、血钙，随访3个月，比较两组生活质量。[结果] 治疗后，观察组总有效率高于对照组（P＜0.05），高敏C反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、血磷水平、维生素B12、叶酸均低于对照组（P＜0.05，P＜0.01），血清铁蛋白、生活质量评分均高于对照组（P＜0.01）；全段甲状旁腺素（iTPH）、血钙水平治疗前后组内比较、治疗后组间比较，差异均无统计学意义（P＞0.05）。[结论] 尿毒清颗粒联合碳酸钙、血液灌流治疗血液透析高磷血症可提高治疗总有效率，改善炎性反应和营养状况，降低血磷水平，不影响iPTH及血钙水平，提高患者生活质量，值得推广。

Abstract:

[Objective] To explore the clinical effect of Niaoduqing Granule combined with calcium carbonate and blood perfusion hemoperfusion in the treatment of hyperphosphatemia after hemodialysis and its influence on the quality of life of patients. [Methods] The 101 patients were randomly divided into the observation group 51，the control group 50. Both groups were given basic treatment such as calcium carbonate and blood perfusion，the observation group added Niaoduqing Granules to the basic treatment，and the control group was given placebo of the same specification. The two groups were treated for 3 months. The clinical efficacy，inflammatory reaction，total parathyroid hormone，anemia，blood phosphorus and blood calcium of the two groups were compared. The two groups were followed up for 3 months to compare the quality of life. [Results] After treatment，the total effective rate of the observation group was higher than that of the control group （<P<0.05），CRP，IL-6，TNF-α and the levels of blood phosphorus，vitamin B12 and folic acid were lower than those of the control group （P<0.05，P<0.01），and the scores of serum ferritin and quality of life were higher than those of the control group （P<0.01）. There was no significant difference in iTPH and blood calcium levels between groups before and after treatment （P>0.05）. [Conclusion] Niaoduqing Granule combined with calcium carbonate and blood perfusion can improve the total effective rate of treatment，improve the inflammatory reaction and nutritional status，reduce the blood phosphorus level，do not affect the iPTH and blood calcium level，and improve the quality of life of patients. It is worthy of promotion.