基于文献计量学对中医药干预氧化应激的可视化分析

Visual analysis of traditional Chinese medicine intervention in oxidative stress based on bibliometrics

关键词:  中医药  氧化应激  文献计量学  可视化分析  Citespace  Vosviewer

Key words:  traditional Chinese medicine  oxidative stress  bibliometric  visual analysis  Citespace  Vosviewer

摘要:

[目的] 研究旨在应用文献计量学整合知识图谱， 探究近年来中医药干预氧化应激的国内外研究发展趋势、研究现状和热点。[方法] 通过检索 Web of Science（WOS）和中国知网数据库（CNKI）， 获取建库至今有关中医药干预氧化应激的文献， 使用 Citespace 6.1.6R 和 Vosviewer1.6.18 软件进行可视化分析， 共纳入中文文献 4 739 篇， 英文文献3 570 篇。[结果] 该领域研究发文在近 30 年来呈整体上升趋势， 研究机构多以国内中医药大学为主， 发文量最多的机构为北京中医药大学。关键词分析显示中医药干预氧化应激的机制研究以及临床应用一直占据该领域研究的重点内容并持续发展， 有效组方、临床疗效评价、针灸治疗以及“铁死亡” “自噬”等相关前沿理论的探究可能成为新的研究热点， 具有重要潜在价值。[结论] 中医药干预氧化应激领域已积累了大量研究成果， 下一步需要开展更多高质量临床试验， 从而促进已有研究成果的临床转化， 完善疾病的中西医结合临床诊疗模式。

Abstract:

[Objective] This study employed bibliometric tools to review the studies of traditional Chinese medicine （TCM） intervention in oxidative stress in recent years，aiming to explore the research trends，status and hotspots at home and abroad. [Methods] The literature on the intervention of traditional Chinese medicine in oxidative stress was obtained by searching CNKI database and WOS. Visualization analysis was performed using Citespace 6.1.6R and Vosviewer1.6.18 software. A total of 4 739 Chinese literatures and 3 570 English literatures were included. [Results] The results showed that the number of published papers in this field had shown an overall upward trend in the past 30 years. Most of the research institutions were Chinese medicine universities，and Beijing University of Chinese Medicine had the largest number of published papers. Keyword analysis showed that the mechanism of TCM intervention in oxidative stress and its clinical application had been the focus of this field and continued to develop. The exploration of effective prescription formulation，clinical efficacy evaluation，acupuncture treatment，“ferroptosis”“autophagy” and other related frontier theories may become a new research hotspot，with important potential value. [Conclusion] The development prospect of this field is promising， but more high-quality clinical trials are still needed to promote the translation of existing results to the clinic，so as to improve the comprehensive clinical diagnosis and treatment model.