益气通络法耳穴铜砭刮痧对阴虚血瘀型2型糖尿病患者血糖控制、炎症因子的影响

Effect of Tongbian Guasha at auricular point of Yiqi Tongluo method on blood glucose control and inflammatory factors in Type 2 diabetes patients with yin deficiency and blood stasis

关键词:  2型糖尿病  耳穴铜砭刮痧  益气通络法  血糖控制  炎症因子

Key words:  type 2 diabetes mellitus  Tongbian Guasha at auricular point  Yiqi Tongluo method  blood glucose control  inflammatory factor

摘要:

[目的] 探讨益气通络法耳穴铜砭刮痧对阴虚血瘀型2型糖尿病（T2DM）患者血糖控制、炎症因子的影响。[方法] 选择2021年9月—2022年9月南京中医药大学附属张家港医院收治的100例阴虚血瘀型T2DM患者，按随机数字表法随机分为两组，每组各50例。对照组常规降糖治疗，观察组在常规降糖治疗基础上增加益气通络法耳穴铜砭刮痧治疗12周。比较两组疗效、中医证候积分、血糖控制、脂代谢、炎症因子和不良反应差异。[结果] 观察组治疗总有效率大于对照组（96.00% vs. 80.00%，P<0.05）。两组治疗后口干多饮、肢体麻痛、五心烦热、气短自汗、大便秘结、腰膝酸软中医证候积分以及空腹血糖（FPG）、空腹胰岛素（FINS）、餐后2 h血糖（2 h PBG）、糖化血红蛋白（HbA1c）、胰岛素抵抗指数（HOMA-IR）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）均较治疗前降低（P<0.05），且观察组治疗后上述中医证候积分、FPG、FINS、2 h PBG、HbA1c、HOMA-IR、TC、LDL-C、TNF-α、IL-6、IL-1β低于对照组（P<0.05）。[结论] 益气通络法耳穴铜砭刮痧可改善糖脂代谢和胰岛素抵抗，降低炎症反应，提高阴虚血瘀型T2DM临床治疗效果。

Abstract:

[Objective] To investigate the effect of Tongbian Guasha at auricular point of Yiqi Tongluo method on blood glucose control and inflammatory factors in Type 2 diabetes mellitus (T2DM) patients with yin deficiency and blood stasis. [Methods] 100 patients with T2DM with both yin deficiency and blood stasis admitted to our hospital from September 2021 to September 2022 were randomly divided into two groups with 50 cases in each group by number table method. The control group was treated with routine hypoglycemic therapy,and the observation group was treated with Tongbian Guasha at auricular point of Yiqi Tongluo method for 12 weeks on the basis of routine hypoglycemic therapy. The efficacy,traditional Chinese medicine(TCM) symptom score,blood glucose control,lipid metabolism,inflammatory factors and adverse reactions were compared between the two groups. [Results] The total effective rate of the observation group was higher than that of the control group (96.00% vs. 80.00%,P<0.05). After treatment,the two groups had dry mouth,excessive drinking,limb numbness pain,five upset and hot,Shortness of breath,perspiration,constipation,lumbar and knee acid and soft TCM syndrome scores,fasting blood glucose (FPG),fasting insulin (FINS),postprandiall 2 h blood glucose (2 h PBG),glycated hemoglobin (HbA1c),insulin resistance index (HOMA-IR),total cholesterol (TC),low density lipoprotein cholesterol (LDL-C),tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6) and interleukin-1β (IL-1β) were all lower than those before treatment (P<0.05),and the TCM syndrome scores,FPG,FINS,2 h PBG,HbA1c,HOMA-IR,TC,LDL-C,TNF-α,IL-6 and IL-1β in the observation group after treatment were lower than those in the control group (P<0.05). [Conclusion] Tongbian scraping at auricular point of Yiqi Tongluo method can improve glucose and lipid metabolism and insulin resistance,reduce inflammation and improve the clinical therapeutic effect of T2DM with yin deficiency and blood stasis.