改良金黄膏辅助治疗急性胰腺炎腑实热结证的临床观察

Clinical observation on the adjuvant treatment of acute pancreatitis with Fu excess heat syndrome with modified Jinhuang ointment

关键词:  急性胰腺炎  改良金黄膏  中医证候积分  疼痛  炎性细胞因子

Key words:  acute pancreatitis  modified Jinhuang ointment  Chinese medicine syndrome scores  pain  inflammatory cytokines

摘要:

[目的] 探讨改良金黄膏治疗急性胰腺炎（AP）腑实热结证的临床效果。[方法] 选取2021年10月—2022年10月河北省沧州中西医结合医院60例腑实热结证AP患者为研究对象，按照随机数字表法分为对照组30例和研究组30例。对照组采用常规西医治疗，研究组在对照组基础上给予改良金黄膏外敷。比较两组治疗前后中医证候积分、视觉模拟评分法（VAS）评分及炎性细胞因子[C反应蛋白（CRP）、白细胞介素（IL）-6、IL-1β及肿瘤坏死因子-α（TNF-α）]水平，统计胃肠功能恢复时间、临床疗效及不良反应发生情况。[结果] 治疗后，研究组总有效率为96.67%，高于对照组的80.00%（P＜0.05）；研究组中医证候主症、次症及总积分低于对照组（P＜0.05）；研究组CRP、IL-6、IL-1β、TNF-α水平及VAS评分低于对照组（P＜0.05）；研究组腹胀、肠鸣音、进食及排便恢复时间均短于对照组（P＜0.05），差异均具有统计学意义。两组不良反应发生率比较，差异无统计学意义（P＞0.05）。[结论] AP患者常规治疗同时应用改良金黄膏可有效缓解其临床症状，减轻疼痛程度、炎症反应，促进胃肠功能恢复，提升疗效，且不良反应少。

Abstract:

[Objective] To explore the effect of acute pancreatitis（AP） with Fu excess heat syndrome with modified Jinhuang ointment. [Methods] Sixty patients with AP with fu excess heat syndrome admitted to our hospital from October 2021 to October 2022 were selected and divided into control group（30 case） and study group（30 case） according to the random number table method. The control group received conventional western medicine treatment，while the research group received modified Jinhuang ointment external application on the basis of the control group. Compare the traditional Chinese medicine syndrome scores，visual analogue scale（VAS） scores and inflammatory cytokines [C-reactive protein（CRP），interleukin（IL）-6，IL-1β and tumor necrosis factor-α（TNF-α）] level between the two groups before and after treatment，calculate the recovery time of gastrointestinal function，clinical efficacy，and incidence of adverse reactions. [Results] After treatment，the total effective rate of the study group was 96.67%，which was higher than 80.00% of the control group（P＜0.05）. The main symptoms，secondary symptoms，and total scores of traditional Chinese medicine syndromes in the research group were lower than those in the control group（P＜0.05）. The level of CRP，IL-6，IL-1β，TNF-α and VAS score in the research group were lower than those in the control group（P＜0.05）. The recovery time of abdominal distension，bowel sounds，eating and defecation in the study group was shorter than that in the control group（P＜0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups（P＞0.05）. [Conclusions] The combined use of modified Jinhuang ointment in routine treatment for AP patients can effectively alleviate their clinical symptoms，alleviate pain levels，inflammatory reactions，promote gastrointestinal function recovery，improve efficacy，and have fewer adverse reactions.