千金苇茎汤联合酚妥拉明治疗支气管扩张的疗效及对患者血清指标及免疫功能的影响

Effect of Qianjin Weijing Decoction combined with phentolamine on bronchiectasis and its influence on serum indexes and immune function of patients

关键词:  支气管扩张  千金苇茎汤  酚妥拉明  血清指标  免疫功能

Key words:  bronchiectasis  Qianjin Weijing Decoction  phentolamine  serum index  immune function

摘要:

[目的] 分析千金苇茎汤联合酚妥拉明治疗支气管扩张的疗效及对患者血清指标和免疫功能的影响。[方法] 选取罗湖区中医院2020年6月—2022年6月收治的150例支气管扩张患者为研究对象进行筛查，共有147例患者筛查成功，按照随机数字表法分为千金苇茎汤组48例、酚妥拉明组46例、联合组53例，千金苇茎汤组患者采用千金苇茎汤治疗，酚妥拉明组患者采用酚妥拉明治疗，联合组患者使用千金苇茎汤、酚妥拉明联合治疗，千金苇茎汤组、酚妥拉明组各40例患者完成治疗，联合组43例患者完成治疗，观察各组患者治疗前后肺功能、血气分析指标、炎症指标、免疫功能、总有效率情况。[结果] 与治疗前相比，治疗后各组患者第1秒用力呼气容积（FEV1）、最大肺活量（FVC）、最大呼气流量（PEF）、最大通气量（MVV）、血氧分压（PaO₂）、血氧饱和度（SaO₂）、CD3⁺、CD8⁺、CD4⁺/CD8⁺升高，血二氧化碳分压（PaCO₂）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）降低，且研究组高于/低于千金苇茎汤组、酚妥拉明组（P<0.05）。与千金苇茎汤组、酚妥拉明组相比，联合组治疗总有效率较高（P<0.05）。[结论] 支气管扩张患者经千金苇茎汤、酚妥拉明联合治疗，症状得到有效控制，肺功能、血气指标得到恢复，患者炎症状态得到有效改善，免疫功能显著提升，疗效显著。

Abstract:

[Objective] To analyze the curative effect of Qianjin Weijing Decoction combined with phentolamine on bronchiectasis and its influence on serum indexes and immune function of patients. [Methods] The 150 patients with bronchiectasis admitted to Luohu District Traditional Chinese Medicine Hospital from June 2020 to June 2022 were selected as the research subjects. A total of 147 patients were successfully screened, and the 147 patients who were successfully screened were randomly divided into Qianjin Weijing Decoction group (48 cases), phenotolamine group(46 cases) and combination group(53 cases) using random number table method. Qianjin Weijing Decoction group patients were treated with Qianjin Weijing Decoction, while phenotolamine group patients were treated with phenotolamine. The combination group of patients was treated with Qianjin Weijing Decoction and phentolamine. A total of 40 patients in the Qianjin Weijing Decoction and phentolamine groups completed the treatment, while 43 patients in the combination group completed the treatment. The lung function, blood gas analysis indicators, inflammation indicators, immune function and total effective rate of patients in each group were observed before and after treatment. [Results] Compared with before treatment, the forced expiratory volume in 1 second(FEV1), maximum vital capacity(FVC), maximum expiratory flow(PEF), maximum ventilation volume(MVV), and partial pressure of oxygen(PaO₂) in each group after treatment, blood oxygen saturation(SaO₂), CD3⁺, CD8⁺, CD4⁺/CD8⁺ increase, blood carbon dioxide partial pressure(PaCO₂), interleukin-6(IL-6), interleukin-8(IL-8), tumor necrosis factor-α(TNF-α) decreased, and the study group was higher/lower than the Qianjin Weijing Decoction group and the phentolamine group(P<0.05). Compared with the Qianjin Weijing Decoction group and the phentolamine group, the total effective rate of the combined group was higher(P<0.05). [Conclusion] After the combined treatment of Qianjing Weijin Decoction and phentolamine, the symptoms of the patients with bronchiectasis were effectively controlled, the lung function and blood gas indexes were recovered, the inflammatory state of the patients was effectively improved, and the immune function was significantly improved.