丹芪偏瘫胶囊治疗脑卒中的研究进展

Research progress on the efficacy and mechanism of Danqi Piantan Capsule in the treatment of stroke

关键词:  丹芪偏瘫胶囊  脑卒中  实验研究  临床应用  作用机制

Key words:  Danqi Piantan Capsule  stroke  experimental study  clinical application  mechanism

摘要:

丹芪偏瘫胶囊,有益气活血、开窍醒脑、活血通络的功效,用于气虚血瘀型缺血性中风病中经络恢复期。主要成分有黄芪甲苷、丹酚酸B、芍药苷、Z-藁本内酯、龙脑、α-细辛脑、β-细辛脑等,通过影响多靶点多通路发挥抗脑卒中作用。在动物实验及临床研究中均证实:丹芪偏瘫胶囊参与脑卒中及并发症的治疗,发挥作用与抗炎、抗细胞凋亡、神经保护和神经再生、抗氧化应激、增加脑血流量、改善认知功能有关。对丹芪偏瘫胶囊治疗脑卒中及并发症的临床研究和基础研究进行综述,以期为该制剂的再开发利用提供理论依据。

Abstract:

Danqi Piantan Capsule has the effects of benefiting qi and activating blood circulation,inducing resuscitation,activating blood circulation and dredging collaterals,used in the recovery period of meridians of ischemic stroke of qi deficiency and blood stasis type. The main ingredients are astragaloside A,salvianolic acid B,paeoniflorin,Z-ligustilide,borneol,α-asarone,β-asarone,which exert anti stroke effects by acting on multiple targets and pathways. In animal experiments and clinical studies,it has been confirmed that Danqi Piantan Capsule is involved in the treatment of stroke and complications,and its effects are related to anti-inflammatory,anti-apoptotic,neuroprotective and nerve regeneration,antioxidant stress,increased cerebral blood flow,and improved cognitive function. This article reviews the clinical research and basic research of Danqi Piantan Capsule in the treatment of stroke and complications,in order to provide a theoretical basis for the further development and utilization.