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| 生物碱类天然药物抗痛风作用及作用机制的研究进展 |
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卡玉秀1,2,3, 刘维1,2, 丁久力1,2,3, 林芳芳1,2,3, 陈婌娟1,2,3, 顾庆香1,2,3, 岳青云1,2,3, 樊一桦4
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1.天津中医药大学第一附属医院风湿免疫科, 天津 300381;2.国家中医针灸临床医学研究中心, 天津 300381;3.天津中医药大学研究生院, 天津 301617;4.成都中医药大学附属医院风湿免疫科, 成都 610072
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| 摘要: |
| 痛风是由于机体嘌呤代谢异常和(或)尿酸排泄障碍所致的一组异质性疾病。生物碱是一类含有氮的有机化合物,广泛存在于植物中,用于痛风等多种疾病引起的炎症反应。通过查阅国内外最新相关文献报道,对生物碱抗痛风作用及作用机制的研究进展进行综述,以期为生物碱的进一步研究和临床应用提供科学依据和理论指导。 |
| 关键词: 生物碱 痛风 研究进展 |
| DOI：10.11656/j.issn.1672-1519.2023.12.19 |
| 分类号:R285.5 |
| 基金项目:国家自然科学基金面上项目(82074377,81673927);国家自然科学基金青年科学基金项目(82305202)。 |
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| Progress on the anti-gout effect and action mechanism of alkaloid natural drugs |
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KA Yuxiu1,2,3, LIU Wei1,2, DING Jiuli1,2,3, LIN Fangfang1,2,3, CHEN Shujuan1,2,3, GU Qingxiang1,2,3, YUE Qingyun1,2,3, FAN Yihua4
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1.Department of Rheumatism, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China;2.National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China;3.Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;4.Department of Rheumatism and Immunity, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
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| Abstract: |
| Gout is a heterogeneous group of diseases caused by abnormal purine metabolism and(or) impaired excretion of uric acid.Alkaloids are a class of organic compounds containing nitrogen that are widely found in plants and used for inflammatory reactions caused by many diseases such as gout. By consulting the latest relevant literature reports at home and abroad,this paper summarizes the research progress of the effect and mechanism of alkaloids against gout,in order to provide scientific basis and theoretical guidance for further research and clinical application of alkaloids. |
| Key words: alkaloids gout research progress |
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