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| 基于“内燥阴伤”探讨滋燥养荣汤改善EGFRIs相关皮肤干燥的理论探讨 |
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郑玉敏1,2, 张旭1,2, 俞仪萱1,2, 鲁星妤1,2, 董慧静1,2, 崔慧娟2
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1.北京中医药大学, 北京 100029;2.中日友好医院中西医结合肿瘤内科, 北京 100029
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| 摘要: |
| 皮肤干燥是服用EGFRIs非小细胞肺癌患者的后期主要不良事件,属“内燥”范畴;古方滋燥养荣汤主治“皮肤皴揭、筋燥爪干”,可滋阴养血、润燥止痒,改善EGFRIs相关皮肤干燥。在“内燥阴伤”的中医理论指导下,将EGFRIs相关皮肤干燥的疾病本质“燥”作为锚点,EGFRIs相关皮肤演变终点“皮肤老化”作为表观,滋燥养荣汤中药组成的现代药理研究作为支撑,探讨滋燥养荣汤改善EGFRIs相关皮肤干燥的理论,用于指导临床。 |
| 关键词: 滋燥养荣汤 表皮生长因子受体抑制剂 皮肤干燥 内燥 中医理论 |
| DOI：10.11656/j.issn.1672-1519.2024.01.12 |
| 分类号:R734.2 |
| 基金项目:国家自然科学基金项目(81873396); 首都卫生发展科研专项(2022-2-4065)。 |
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| To explore the theoretical framework of Zizao Yangrong Decoction in improving EGFRIs-related xerosis based on “endogenous dryness injuries yin” |
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ZHENG Yumin1,2, ZHANG Xu1,2, YU Yixuan1,2, LU Xinyu1,2, DONG Huijing1,2, CUI Huijuan2
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1.Beijing University of Chinese Medicine, Beijing 100029, China;2.Department of Oncology, Integrated Chinese and Western Medicine, China-Japan Friendship Hospital, Beijing 100029, China
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| Abstract: |
| Xerosis which belongs to “endogenous dryness” is one of major adverse events in ending of those patients who take EGFRIs for non-small cell lung cancer. Zizao Yangrong Decoction that is an ancient prescription used for chapping skin and tendon dryness,it can improve EGFRIs-related xerosis by nourishing yin and blood,moistening dryness and relieving itching. Under the traditional Chinese medicine theory of “endogenous dryness injuries yin”,the essence “dryness” of EGFRIs-related xerosis was regarded as the anchor,the ending skin of EGFRIs is “skin aging” which was taken as appearance,the modern pharmacology research of Zizao Yangrong Decoction was used for support. In end,the theoretical framework of Zizao Yangrong Decoction for improving EGFRIs-related xerosis was established for guiding syndrome differentiation. |
| Key words: Zizao Yangrong Decoction EGFRIs xerosis endogenous dryness theory of traditional Chinese medicine |
