基于线粒体功能探讨培宗气理论治疗慢性阻塞性肺疾病的机制研究

Based on the function of mitochondria to explore the internal mechanism of zongqi theory in treating of chronic obstructive pulmonary disease

关键词:  慢性阻塞性肺疾病  宗气理论  培土生金  线粒体

Key words:  chronic obstructive pulmonary disease  zongqi theory  peitu shengjin  mitochondria

摘要:

慢性阻塞性肺疾病(COPD)是呼吸系统的常见病和多发病,由于其较高的致残率,对患者生活质量和社会经济产生了严重的负面影响。中医学认为“虚、痰、瘀”是其核心病机,而宗气的盛衰贯穿其病机演变全程。培土生金法为宗气理论治疗COPD的代表性治法现已广泛用于COPD的临床治疗。西医证实线粒体功能和形态障碍是COPD病理及病理生理学发生发展的重要生物学机制。文章从“虚、痰、瘀”与线粒体功能的内在关系出发,探讨宗气理论和培土生金法在COPD治疗中的作用及机制,以期为其临床应用提供依据及指导。

Abstract:

Chronic obstructive pulmonary disease(COPD) is a common and frequently occurring disease of the respiratory system. Due to its high disability rate,it has a serious negative impact on the quality of life and socio-economic development of patients. Traditional Chinese medicine believes that “deficiency,phlegm,and blood stasis” are its core pathogenesis,and the rise and fall of zongqi runs through the entire evolution of its pathogenesis. The method of peitu shengjin is a representative treatment method for COPD based on the theory of zongqi,which has been widely used in clinical treatment of COPD. Modern medicine has confirmed that mitochondrial functional and morphological disorders are important biological mechanisms for the occurrence and development of COPD pathology and pathophysiology. This article starts from the internal relationship between “deficiency,phlegm,blood stasis” and mitochondrial function,and explores the role and mechanism of zongqi theory and the method of cultivating soil and generating gold in the treatment of COPD,in order to provide basis and guidance for its clinical application.