心力衰竭气虚血瘀证相关生物学标志物研究述评与展望

Review and prospect of biological markers related to heart failure with qi deficiency and blood stasis syndrome

关键词:  心力衰竭  气虚血瘀证  生物标志物

Key words:  heart failure  qi deficiency and blood stasis syndrome  biomarker

摘要:

心力衰竭是全球发病率和病死率都很高的心血管疾病，气虚血瘀证是心血管疾病相关证候研究的热点之一，在心力衰竭的不同阶段均可有气虚血瘀的证候表现，找到证候的特异性标志物，并作为微观辨证依据，成为目前中医药防治心力衰竭研究的焦点。心力衰竭临床应用的常见生化标志物有B型利钠肽、N末端B型利钠肽原、心肌肌钙蛋白、炎症标志物、心肌纤维化标志物等。此外，基因组、蛋白质组、代谢组等“多组学”在生物标志物研究中应用广泛，为探索潜在标志物提供依据。文章总结了常见生化标志物、多组学标志物在心力衰竭气虚血瘀病证诊断、预后方面的研究现状，同时探讨“病证结合”生物标志物研究方法上存在的问题，以期进一步规范和优化中医证型生物标志物的研究。

Abstract:

Heart failure is a common cardiovascular disease with high morbidity and mortality rates worldwide. qi deficiency and blood stasis syndrome is one of the hot topics in cardiovascular disease-related syndrome research，and it can manifest as a syndrome at different stages of heart failure. The identification of specific markers of syndromes has become the focus of current research on prevention and treatment of heart failure. Markers in clinical biochemical indicators of heart failure include B-type natriuretic peptid，N-terminal pro-B-type natriuretic peptide，cardiac troponin，inflammatory biomarkers，markers of myocardial fibrosis and so on. Additionally，multi-omics technologies such as genomics，proteomics，and metabolomics have been widely applied in biomarker research to explore potential biomarkers. This article summarizes the current research status of markers in clinical biochemical indicators and multi-omics markers in the diagnosis and prognosis of heart failure with qi deficiency and blood stasis syndrome，while also discussing the problems in the “disease-syndrome combination” biomarker research method，aiming to further standardize and optimize the study of traditional Chinese medicine syndrome biomarkers.