针刺治疗慢性荨麻疹伴发失眠患者临床疗效的真实世界研究

Real-world study on the clinical efficacy of acupuncture in the treatment of patients with chronic urticaria accompanied by insomnia

关键词:  慢性荨麻疹  失眠  针刺  真实世界研究

Key words:  chronic urticaria  insomnia  acupuncture treatment  real world research

摘要:

[目的] 基于真实世界观察慢性荨麻疹患者失眠发生情况以及针刺治疗慢性荨麻疹伴发失眠的临床疗效。[方法] 采用真实世界回顾性队列研究，纳入217例确诊为慢性荨麻疹并实施针刺治疗的患者，根据治疗前的匹兹堡睡眠质量指数评分筛选出慢性荨麻疹伴发失眠患者80例，采集该80例患者的临床基本资料、相关指数评分、治疗方案，比较不同年龄、性别、病程、辨证分型的失眠发生率；观察失眠患者在针刺治疗前后视觉模拟评分法（VAS）、7 d荨麻疹活动性评分（UAS7）、皮肤病生活质量指数评分（DLQI）、匹兹堡睡眠质量指数评分（PSQI）的差异，综合分析针刺治疗慢性荨麻疹伴发失眠患者的临床疗效。[结果] 不同性别、年龄、病程，慢性荨麻疹患者伴发失眠差异无统计学意义；失眠患者在针刺治疗前各症状积分均高于治疗后，其差异具有统计学意义（P＜0.05）。[结论] 慢性荨麻疹患者出现失眠与性别、年龄、病程无关，可能与荨麻疹的瘙痒症状相关，失眠患者治疗前的症状积分高于治疗后，针刺治疗能有效缓解荨麻疹瘙痒症状并改善失眠。

Abstract:

[Objective] To observe the occurrence of insomnia in patients with chronic urticaria and the clinical efficacy of acupuncture in the treatment of chronic urticaria with insomnia based on real world. [Methods] In a real-world retrospective cohort study，217 patients diagnosed with chronic urticaria and treated with acupuncture were included. The 80 patients with chronic urticaria accompanied by insomnia were screened out according to Pittsburgh sleep quality index score（PSQI） before treatment，and the basic clinical data，related index score and treatment plan of the 80 patients were collected. The incidence of insomnia in different age，sex，course of disease and syndrome differentiation was compared. And the differences of visual analog scale（VAS），7-day urticaria activity score（UAS7），dermatological life quality index（DLQI），PSQI in patients with insomnia were observed before and after the acupuncture treatment，and comprehensively analyze the clinical efficacy of acupuncture in treating the patients with chronic urticaria accompanied by insomnia. [Results] There was no statistically significant difference in gender，age，and disease duration of chronic urticaria patients with insomnia. All symptom scores of insomnia patients before acupuncture treatment were higher than those after treatment，and the differences were statistically significant（P<0.05）. [Conclusion] Insomnia in patients with chronic urticaria has nothing to do with gender，age，and disease duration，but it may be related to the itching symptoms of urticaria. The symptom scores of patients with insomnia before treatment were higher than that after treatment，and acupuncture treatment can effectively relieve the itching symptoms of urticaria and improve insomnia.