从“脾肾亏虚”探讨肠道菌群与膝骨关节炎的关系

Exploring the relationship between intestinal flora and osteoarthritis of the knee based on the “spleen and kidney deficiency”

关键词:  膝骨关节炎  肠道菌群  虚证

Key words:  osteoarthritis of the knee  intestinal microbiota  deficiency syndrome

摘要:

膝骨性关节炎是以膝关节软骨退行性病变和继发性骨质增生为特征的慢性关节疾病，随着年龄及人口老龄化的增长具有高致病率，然而当前对于膝骨性关节炎的治疗手段更多偏向于从症状控制、关节置换出发，尚且缺乏从肠道菌群种类、数量构成比的角度阐述肠道微生态紊乱与膝骨性关节炎治疗的关系。笔者认为老年脾肾亏虚是膝骨性关节炎发病的根本因素，因此以八纲辨证中的虚证为基础，阐明在脾肾亏虚的病理状态下肠道菌群丰度结构的改变，探讨其与膝骨性关节炎的关系，并通过补肾健脾法治疗膝骨性关节炎，解释肠道菌群多样化对疾病的作用机制，为针对膝骨性关节炎虚证患者提出新的治疗思路。

Abstract:

Knee osteoarthritis is a chronic joint disease characterized by degenerative changes in knee joint cartilage and secondary bone proliferation. With the growth of age and population aging，it has a high incidence rate. However，current treatments for knee osteoarthritis tend to focus more on symptom control and joint replacement，lacking an explanation of the relationship between intestinal microbiota dysbiosis and the treatment of knee osteoarthritis from the perspective of the types and quantities of intestinal flora. The author believes that deficiency of the spleen and kidney in the elderly is the fundamental factor in the onset of knee osteoarthritis. Therefore，based on the deficiency syndrome in the eight-line syndrome differentiation，the author will clarify the changes in the composition ratio of intestinal flora abundance under the pathological state of spleen and kidney deficiency，explore the relationship between it and knee osteoarthritis，and treat knee osteoarthritis by invigorating kidney and invigorating spleen，and explain the mechanism of intestinal flora diversification on the disease. This paper provides new treatment ideas for patients with deficiency syndrome of knee osteoarthritis.