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| 中药内生菌代谢产物及其药理活性研究进展 |
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刘梅1,2, 彭宇辉2, 蒲洪2, 刘建新1,2,3
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1.南华大学药学院, 衡阳 421001;2.湖南医药学院药学院, 新型抗体药物及其智能运输系统湖南省重点实验室, 中药合成生物学研究湖南省重点实验室, 怀化 418000;3.湖南中医药大学科技创新中心, 长沙 410208
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| 摘要: |
| 中药内生菌的代谢产物是先导化合物的重要来源，已成为药学领域研究的热点。文章综述了近年来从植物中研究发现的主要内生菌，并对其代谢产物及其药理活性进行归纳分析，发现内生菌可产生与天然药物化学相同的有效成分，主要包括萜类、生物碱类和蒽醌类等。活性测试表明，内生菌的代谢产物具有较显著的药理活性，主要表现在抗病原微生物、抗肿瘤和抗炎等方面，为先导化合物的发现研究提供借鉴和新途径。值得注意的是，内生菌也被证实有利于药用植物的生长，甚至能提高药用植物的抗病虫能力，为药用植物的改良栽培提供新思路。 |
| 关键词: 内生菌 代谢产物 药理活性 中药 |
| DOI：10.11656/j.issn.1672-1519.2025.02.19 |
| 分类号:R282 |
| 基金项目:国家自然科学基金面上项目（82274178）；湖南省科学技术厅科技创新重大项目（2020SK1020）；怀化市五溪青年人才支持计划。 |
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| Advances in the studies of endophyte’s metabolites and their pharmacological activities from traditional Chinese medicine |
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LIU Mei1,2, PENG Yuhui2, PU Hong2, LIU Jianxin1,2,3
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1.School of Pharmaceutical Science, University of South China, Hengyang 421001, China;2.Hunan Province Key Laboratory for Antibody-based Drug and Intelligent Delivery System, Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China;3.Institute of Innovation and Applied Research in Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China
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| Abstract: |
| The metabolites of endophytic bacteria in traditional Chinese medicine are important sources of lead compounds，which have become a research hotspot in the field of pharmacy. In this review，we summarized the main endophytes found in plants in recent years and analyzed their metabolites and metabolites’ pharmacological activities. It was found that endophytes could produce the same effective ingredients as natural drugs，mainly including terpenoids，alkaloids，and anthraquinones. The results of pharmacological activity tests showed that the metabolites of endophytic bacteria had significant pharmacological activities，mainly in anti-pathogenic microorganisms，anti-tumor，and anti-inflammatory，which provided a reference and new way for the discovery and research of lead compounds. It is worth noting that endophytes have also been proven to be beneficial to the growth of medicinal plants，and even improve the resistance of medicinal plants to diseases and insects，which provides new ideas for the improved cultivation of medicinal plants. |
| Key words: endophyte metabolite pharmacological activity traditional Chinese medicine |
