| 摘要: |
| 心肌缺血再灌注损伤是急性心肌梗死血流复通后常见的并发症，其发病机制涉及氧化应激、线粒体功能障碍、炎症反应及多种程序性细胞死亡等复杂的病理过程。三七皂苷R1（NG R1）是三七中特有的活性成分，研究表明其在心肌缺血再灌注损伤中具有心肌保护作用，NG R1可通过调控氧化应激、炎症反应、细胞死亡及线粒体功能等多个病理环节减轻心肌损伤。然而NG R1可能因为生物利用度低的问题限制了临床发展，但NG R1与其他天然活性成分联合应用表现出强大的协同保护作用。文章系统综述NG R1抗心肌缺血再灌注损伤的主要药理作用及相关机制，并对其单体应用局限及协同组合作用研究进行讨论，目的是为天然药物改善心肌缺血再灌注损伤提供参考。 |
| 关键词: 心肌缺血再灌注 三七皂苷R1 益气活血 多靶点 协同作用 |
| DOI：10.11656/j.issn.1672-1519.2026.08.15 |
| 分类号:R542.2 |
| 基金项目:国家自然科学基金面上项目（82374075）；泰山学者青年专家项目（tsqn202306188）。 |
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| Research progress on the pharmacological effects and mechanisms of notoginsenoside R1 against myocardial ischemia-reperfusion injury |
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WANG Yuyao1, WANG Taiyi2,3,4
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1.Innovation Research Institute of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China;2.Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan 250355, China;3.Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China;4.Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
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| Abstract: |
| Myocardial ischemia/reperfusion (I/R) injury is a prevalent complication following reperfusion therapy for acute myocardial infarction. Its pathogenesis involves a complex interplay of oxidative stress, inflammatory responses, mitochondrial dysfunction, and various forms of programmed cell death. Notoginsenoside R1 (NG R1), a unique bioactive saponin derived from Panax notoginseng, has demonstrated significant cardioprotective effects against I/R injury. Mechanistically, NG R1 attenuates myocardial damage by modulating multiple pathological pathways, including the mitigation of oxidative stress and inflammation, regulation of cell death signaling, and preservation of mitochondrial function. However, the clinical translation of NG R1 as a monotherapy is hindered by its low bioavailability. NG R1 exerts synergistic protective effects when combined with other natural bioactive compounds. This review systematically summarizes the primary pharmacological effects and underlying mechanisms of NG R1 in combating myocardial I/R injury. Furthermore, we critically discuss the limitations associated with its monotherapeutic application and explore the potential of synergistic combinations. This work aims to provide a theoretical basis and reference for the development of natural drug strategies to improve outcomes in myocardial I/R injury. |
| Key words: myocardial ischemia-reperfusion notoginsenoside R1 Yiqi Huoxue multi-target synergistic effect |
