活血化瘀类中药干预心肌梗死后心室重构的分子机制研究进展

Research progress of molecular mechanism of intervening in ventricular remodeling after myocardial infarction by blood-activating and blood-stasis-eliminating traditional Chinese medicine

关键词:  心肌梗死  心室重构  活血化瘀  分子机制

Key words:  myocardial infarction  ventricular remodeling  activating blood circulation and removing blood stasis  molecular mechanism

摘要:

心肌梗死后心室重构是导致心力衰竭和心血管事件的重要因素，活血化瘀类药物作为传统中医药的代表，在改善心血管疾病方面展现出独特的优势。多种具有活血化瘀功效的中药复方及单体可通过调节细胞程序性死亡、抑制炎症反应、氧化应激、减少心肌纤维化、促进血管新生，减少心肌细胞自噬与焦亡等途径，减轻心肌细胞损伤，促进心室功能恢复。通过对活血化瘀类中药干预心肌梗死后心室重构的分子机制进行深入研究，发现其能够靶向多个分子通路，显示出较高的安全性和有效性，为心肌梗死后心室重构的治疗提供了新的思路。

Abstract:

Ventricular remodeling after myocardial infarction is an important factor leading to heart failure and cardiovascular events. As the representative of traditional Chinese medicine，drugs for activating blood circulation and removing blood stasis show unique advantages in improving cardiovascular diseases. A variety of traditional Chinese medicine compounds and monomers with the effect of promoting blood circulation and removing blood stasis can reduce myocardial cell injury and promote the recovery of ventricular function by regulating programmed cell death，inhibiting inflammatory reaction，oxidative stress，reducing myocardial fibrosis and promoting angiogenesis，reducing autophagy and pyrosis of myocardial cells. Through the in-depth study on the molecular mechanism of activating blood circulation and removing blood stasis in the intervention of ventricular remodeling after myocardial infarction，it was found that it can target multiple molecular pathways，showing high safety and effectiveness，providing a new idea for the treatment of ventricular remodeling after myocardial infarction.