| 摘要: |
| 胃肠安丸由木香、沉香等10味药材组成，具有芳香化浊、理气止痛、健胃导滞的功效，适用于湿浊中阻、食滞内停所致的泄泻、纳差、恶心、呕吐、脘腹痞满、脘腹胀痛等病证。胃肠安丸中含有柚皮苷、橙皮苷、木香烃内酯等活性成分，药理研究表明胃肠安丸具有双向调节胃肠道运动、抗病毒杀菌、抗炎等作用，临床研究表明胃肠安丸可以治疗腹泻、功能性消化不良、肠易激综合征、溃疡性结肠炎等疾病，与其他药物合用可产生协同增效的作用。文章旨在对胃肠安丸的化学成分、药理作用及临床应用进行综述，为其深入开展药效物质基础研究及作用机制研究提供基础。 |
| 关键词: 胃肠安丸 化学成分 临床应用 药理作用 |
| DOI：10.11656/j.issn.1672-1519.2025.11.19 |
| 分类号:R285.6 |
| 基金项目: |
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| Research progress on clinical applications and pharmacological effects of Weichang’an Pill |
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HE Jiali1, WANG Lei2, ZHAO Haining2, CHEN Sulin2
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1.Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2.Tianjin Pharmaceutical Da Ren Tang Group Corporation, Tianjin 300193, China
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| Abstract: |
| Weichang’an Pills is composed of 10 medicinal ingredients including Aucklandiae Radix and Aquilariae Lignum Resinatum. It demonstrates therapeutic effects of resolving turbid dampness through aromatic properties，regulating qi to relieve pain，and strengthening stomach function to promote digestion，applicable for diarrhea，anorexia，nausea，vomiting，epigastric distension，and abdominal pain caused by damp-turbidity stagnation and food retention. The pill contains active components including naringin，hesperidin，and costunolide. Pharmacological studies reveal its dual regulatory effects on gastrointestinal motility，along with antiviral，antibacterial，and anti-inflammatory properties. Clinical research confirms its efficacy in treating diarrhea，functional dyspepsia，irritable bowel syndrome，and ulcerative colitis，demonstrating synergistic effects when combined with other medications. This article aims to review the chemical composition，pharmacological effects，and clinical applications of Weichang’an Pills，establishing foundations for further research on its pharmacodynamic material basis and mechanisms of action. |
| Key words: Weichang’an Pill chemical composition clinical application pharmacological effect |
