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| 芪参益气滴丸成分调控Wnt/β-catenin通路改善心肌梗死后心室重构的研究进展 |
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刘昳佳1, 刘凤敏2, 王朔3, 张晨4, 李彬2, 王艳国1, 徐强5
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1.天津中医药大学第二附属医院康复科, 天津 300250;2.天津中医药大学研究生院, 天津 301617;3.天津中医药大学中医药研究院, 现代中药创制全国重点实验室, 天津 301617;4.天津中医药大学第二附属医院科学技术科, 天津 300250;5.天津中医药大学第二附属医院心血管内科, 天津 300250
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| 摘要: |
| 心肌梗死后心室重构临床表现为心肌损伤或负荷增加后心脏大小、形态和功能等发生改变，是决定急性心肌梗死后心血管事件发生率和远期预后的主要因素。分泌型糖蛋白/β连环蛋白（Wnt/β-catenin）信号通路在心肌梗死后心室重构的炎症反应、心肌细胞纤维化、细胞外基质重构的发生发展中都发挥重要作用。芪参益气滴丸能够显著改善心肌梗死后局部组织微环境，减少心肌炎症反应，抑制心肌肥厚及心肌纤维化，减缓心梗后心室重构，具有整体调控、多靶点治疗等独特优势。其有效成分包括丹参酮ⅡA、黄芪甲苷、人参皂苷等，通过多靶点作用调控Wnt/β-catenin信号通路，减少心肌细胞凋亡、降低氧化应激、促进血管生成及心肌修复，改善心脏功能。然而，芪参益气滴丸成分复杂，需深入探讨其调控Wnt/β-catenin信号通路改善心肌梗死后心室重构的作用机制。今后，还需加强对芪参益气滴丸有效成分的研究，并开展更多的临床试验及体外细胞实验，进行深层次的作用机制和靶点研究。 |
| 关键词: 芪参益气滴丸 心肌梗死后心室重构 Wnt/β-catenin信号通路 心肌纤维化 |
| DOI：10.11656/j.issn.1672-1519.2025.07.18 |
| 分类号:R542.22 |
| 基金项目:河北省中医药类科学研究课题计划项目（T2025076）。 |
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| Research progress on regulating Wnt/β-catenin pathway by component of Qishen Yiqi Dripping Pills to improve ventricular remodeling after myocardial infarction |
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LIU Yijia1, LIU Fengmin2, WANG Shuo3, ZHANG Chen4, LI Bin2, WANG Yanguo1, XU Qiang5
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1.Department of Rehabilitation, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China;2.Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;3.Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, National Key Laboratory of Modern Chinese Medicine Creation, Tianjin 301617, China;4.Department of Science and Technology, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China;5.Department of Cardiology, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China
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| Abstract: |
| The clinical manifestation of ventricular remodeling after myocardial infarction is the change in the size，shape，and function of the heart following myocardial injury or increased load，which is a major factor determining the incidence of cardiovascular events and long-term prognosis after acute myocardial infarction. The Wnt/β-catenin signaling pathway plays an important role in the inflammatory response，myocardial cell fibrosis，and extracellular matrix remodeling associated with ventricular remodeling after myocardial infarction. Qishen Yiqi Dropping Pills can significantly improve the local tissue microenvironment after myocardial infarction，reduce myocardial inflammatory responses，inhibit myocardial hypertrophy and fibrosis，and slow down ventricular remodeling after myocardial infarction，demonstrating unique advantages such as comprehensive regulation and multi-target treatment. Its active components include tanshinone ⅡA，Astragaloside，ginsenoside，etc.，which regulate Wnt/β-catenin signaling pathway through multi-target effects，reduce cardiomyocyte apoptosis，reduce oxidative stress，promote angiogenesis and myocardial repair，and improve cardiac function. However，the components of QiShen Yiqi Dropping Pills are complex，and it is necessary to explore in depth how they regulate the Wnt/β-catenin signaling pathway to improve ventricular remodeling after myocardial infarction. Future research should strengthen the study of the effective components of QiShen Yiqi Dropping Pills and conduct more clinical trials and in vitro cell experiments to investigate the underlying mechanisms and targets in greater depth. |
| Key words: Qishen Yiqi Dripping Pills ventricular remodeling after myocardial infarction Wnt/β-catenin signaling pathway myocardial fibrosis |
